{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:56:22Z","timestamp":1792601782314,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":347,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MO 2017\/4\u20101"],"award-info":[{"award-number":["MO 2017\/4\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Antiphospholipid syndrome (APS) is an autoimmune disease driven by antiphospholipid antibodies (aPL). Currently, APS diagnosis requires a combination of clinical manifestations (thrombosis and\/or obstetric morbidity) and the persistent presence of at least one criteria aPL: anti\u2010cardiolipin antibodies (aCL), anti\u2010\u03b22\u2010glycoprotein I antibodies (a\u03b22GPI) or lupus anticoagulant (LA). Patients with suggestive obstetric symptoms but lacking criteria aPL face diagnostic challenges. Non\u2010criteria aPL screening may enhance discrimination. This study proposes a classification incorporating both criteria and non\u2010criteria antibodies to improve obstetric APS diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood samples from non\u2010pregnant women (<jats:italic>n<\/jats:italic>\u2009=\u200968) with a history of vascular, obstetric, or vascular and obstetric manifestations were analysed. Among them, 30 had previous diagnosis of APS. Healthy women with proven gestational success were included as controls (<jats:italic>n<\/jats:italic>\u2009=\u200916). Criteria and non\u2010criteria (anti\u2010phosphatidylglycerol, anti\u2010phosphatidylethanolamine, anti\u2010phosphatidylinositol, anti\u2010phosphatidylserine and anti\u2010phosphatidic acid) IgG aPL were evaluated by ELISA and coagulation tests. Based on the resulting aPL profile, patients were reclassified. Responsiveness to treatment was obtained from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Criteria aPL levels marginally differentiated women previously managed as obstetric APS from unexplained\/other causes of obstetric morbidity. Including non\u2010criteria aPL improved separation. The proposed classification identified an obstetric APS\u00a0group that exhibits non\u2010criteria aPL and a\u03b22GPI titres below the cut\u2010off but higher than healthy women (7.88 vs. 2.47 SGU, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). Compared to cases of other causes of obstetric morbidity, these patients retrospectively responded better to aspirin and\/or heparin treatment (71.43% vs. 11.11%, <jats:italic>P<\/jats:italic>\u2009=\u20090.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Assessing non\u2010criteria antibodies may identify isolated obstetric APS cases benefiting from established therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.70021","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T10:40:12Z","timestamp":1734086412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Improving diagnosis in patients with obstetric antiphospholipid syndrome through the evaluation of\u00a0non\u2010criteria antibodies"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-4973","authenticated-orcid":false,"given":"Daniel","family":"\u00c1lvarez","sequence":"first","affiliation":[{"name":"Grupo Reproducci\u00f3n, Departamento Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina Universidad de Antioquia UdeA  Medell\u00edn Colombia"},{"name":"Placenta Lab, Department of Obstetrics Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4630-8112","authenticated-orcid":false,"given":"Hephzibah E","family":"Winter","sequence":"additional","affiliation":[{"name":"Placenta Lab, Department of Obstetrics Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6498-0496","authenticated-orcid":false,"given":"Carlos J","family":"Velasquez Franco","sequence":"additional","affiliation":[{"name":"Departamento de Reumatolog\u00eda Cl\u00ednica Universitaria Bolivariana  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4931-5228","authenticated-orcid":false,"given":"Aleida Susana","family":"Castellanos Gutierrez","sequence":"additional","affiliation":[{"name":"Placenta Lab, Department of Obstetrics Jena University Hospital  Jena Germany"},{"name":"BCNatal Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia Fetal i+D Fetal Medicine Research Center  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7022-5270","authenticated-orcid":false,"given":"N\u00faria","family":"Ba\u00f1os","sequence":"additional","affiliation":[{"name":"BCNatal Barcelona Center for Maternal\u2010Fetal and Neonatal Medicine (Hospital Cl\u00ednic and Hospital Sant Joan de D\u00e9u), Institut Cl\u00ednic de Ginecologia, Obstetr\u00edcia i Neonatologia Fetal i+D Fetal Medicine Research Center  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5299-595X","authenticated-orcid":false,"given":"Udo R","family":"Markert","sequence":"additional","affiliation":[{"name":"Placenta Lab, Department of Obstetrics Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3081-0840","authenticated-orcid":false,"given":"\u00c1ngela P","family":"Cadavid","sequence":"additional","affiliation":[{"name":"Grupo Reproducci\u00f3n, Departamento Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina Universidad de Antioquia UdeA  Medell\u00edn Colombia"},{"name":"Grupo de Investigaci\u00f3n en Trombosis, Departamento Medicina Interna, Facultad de Medicina Universidad de Antioquia UdeA  Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-059X","authenticated-orcid":false,"given":"Diana M","family":"Morales\u2010Prieto","sequence":"additional","affiliation":[{"name":"Placenta Lab, Department of Obstetrics Jena University Hospital  Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.1999.0316"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.198119"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1685453"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12341"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902765"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2018.12.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1319"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12634"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318817"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-537704"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-018-0032-6"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-333617"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2014.03.001"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01753.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2023-224609"},{"key":"e_1_2_9_17_1","first-page":"382","article-title":"Non\u2010criteria or seronegative obstetric antiphospholipid syndrome?","volume":"19","author":"Jara LJ","year":"2017","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2019.102407"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.04.065"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.05.006"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.170044"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215213"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01678"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001340"},{"key":"e_1_2_9_25_1","article-title":"Seronegative obstetric antiphospholipid syndrome finally treated successfully","volume":"9","author":"Alghanim KK","year":"2022","journal-title":"Eur J Case Rep Intern Med"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/life10100241"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-021-08862-5"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0378(92)90003-M"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.706743"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15047"}],"container-title":["Clinical &amp; Translational Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cti2.70021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T06:31:19Z","timestamp":1735281079000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cti2.70021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/cti2.70021"],"URL":"https:\/\/doi.org\/10.1002\/cti2.70021","archive":["Portico"],"relation":{},"ISSN":["2050-0068","2050-0068"],"issn-type":[{"value":"2050-0068","type":"print"},{"value":"2050-0068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70021"}}