{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T15:27:14Z","timestamp":1782142034165,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171786"],"award-info":[{"award-number":["82171786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) plays a pivotal role in bone damage associated with inflammatory arthritis such as rheumatoid arthritis (RA). Both systemic lupus erythematosus (SLE) and rheumatoid arthritis exhibit clinical manifestations of inflammatory arthritis, yet the joint bone damage in RA is more severe than that in SLE. The reasons for this differential manifestation remain unclear. This study aimed to determine the role of IgG antibodies in TNF\u2010\u03b1\u2010induced osteoclastogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted cellular experiments to ascertain whether IgG affects TNF\u2010\u03b1\u2010induced osteoclastogenesis and validate the role of IgG in TNF\u2010\u03b1\u2010induced cartilage destruction in mouse models of arthritis through animal studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that IgG promoted TNF\u2010\u03b1\u2010induced osteoclastogenesis by upregulating the expression of tumor necrosis factor receptor 1 (TNFR1) and enhancing the downstream nuclear factor\u2010kappaB (NF\u2010\u03baB) signalling pathway. In the TNF\u2010\u03b1\u2010induced arthritis mouse model, IgG further exacerbated the destruction of articular cartilage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings clarified that IgG aggravated TNF\u2010\u03b1\u2010mediated osteoclastogenesis, further elucidating the mechanistic basis for the divergent manifestations of joint bone damage in SLE and RA.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cti2.70034","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:27:06Z","timestamp":1748237226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["IgG promotes TNF\u2010\u03b1 induced osteoclastogenesis by upregulating the expression of TNFR1 and the NF\u2010\u03baB signalling pathway"],"prefix":"10.1002","volume":"14","author":[{"given":"Haifeng","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Min","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan 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