{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T04:38:33Z","timestamp":1763008713881,"version":"3.45.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":289,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp; Trans Imm"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Eosinophilia, characterised by elevated eosinophil levels, is associated with various allergic and inflammatory conditions. This study aimed to elucidate the genetic determinants of eosinophil levels by examining polygenic risk scores (PRS) and\u00a0identifying significant single nucleotide polymorphisms (SNPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a comprehensive genome\u2010wide association study (GWAS) on eosinophil levels using a large cohort, comprising 221\u2009851 controls (eosinophil levels\u2009\u2264\u20095%) and 11\u2009200 cases (eosinophil levels\u2009&gt;\u20095%) in Taiwan. The analysis included covariates such as age, sex and the first 10 principal components to account for population stratification. Polygenic risk scores were calculated, and their associations with eosinophil levels were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The control group exhibited a mean eosinophil level of 47.81 (SD, 21.08) and was composed of 55.32% females and 44.68% males. The case group had a mean eosinophil level of\u00a043.27 (SD, 22.27) and consisted of 38.6% females and 61.4%\u00a0males. The GWAS identified several SNPs with significant associations, including rs7646596, rs8191981, rs140105250, rs77143352, rs12535759, rs11327184, rs16917546, rs76738175, rs11568075, rs9557175 and rs2801127, with rs7646596 showing the most significant\n                      <jats:italic>P<\/jats:italic>\n                      \u2010value. PRS analysis indicated that individuals with higher polygenic risk scores were significantly more likely to have elevated eosinophil levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identified several genetic loci significantly associated with eosinophil levels, highlighting the polygenic nature of eosinophilia. The robust associations, particularly with SNP rs7646596, offer valuable insights into the genetic underpinnings of eosinophilia and related conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cti2.70050","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T10:45:04Z","timestamp":1760697904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010wide association study and polygenic risk scores of eosinophilia in Taiwan"],"prefix":"10.1002","volume":"14","author":[{"given":"Hsing\u2010Fang","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Medical Research China Medical University Hospital  Taichung Taiwan"},{"name":"Master Program for Digital Health Innovation China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su","family":"Boon\u2010Yong","sequence":"additional","affiliation":[{"name":"Department of Allergy and Immunology China Medical University Children's Hospital  Taichung Taiwan"},{"name":"Department of Medicine, College of Medicine China Medical University  Taichung Taiwan"},{"name":"School of Medicine China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5625-5489","authenticated-orcid":false,"given":"Chi\u2010Ya","family":"Yang","sequence":"additional","affiliation":[{"name":"Johns Hopkins Bloomberg School of Public Health  Baltimore MD USA"},{"name":"Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiu\u2010Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Allergy, Immunology, and Microbiome (A.I.M.) China Medical University Hospital  Taichung Taiwan"},{"name":"Department of Allergy, Immunology, and Rheumatology (AIR) China Medical University Children's Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen\u2010Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Research China Medical University Hospital  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuu\u2010Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Medical Research China Medical University Hospital  Taichung Taiwan"},{"name":"School of Chinese Medicine China Medical University  Taichung Taiwan"},{"name":"Division of Medical Genetics Children's Hospital of China Medical University  Taichung Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology Asia University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.09.022"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3985"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.156015"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.109897"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0047-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.045"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00931-x"},{"key":"e_1_2_10_9_1","first-page":"790","article-title":"GWAS of genetic factors affecting white blood cell morphological parameters in Sardinians uncovers influence of chromosome 11 innate immunity gene cluster on eosinophil morphology","volume":"32","author":"Marongiu M","year":"2023","journal-title":"Hum Mol Genet"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08494"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-015-0050-4"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.24206"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.323"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906312"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2014.00401"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1267LE"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-021-00339-y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-024-01304-9"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.37796\/2211-8039.1302"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.948616"}],"container-title":["Clinical &amp; Translational Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cti2.70050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T04:33:38Z","timestamp":1763008418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cti2.70050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/cti2.70050"],"URL":"https:\/\/doi.org\/10.1002\/cti2.70050","archive":["Portico"],"relation":{},"ISSN":["2050-0068","2050-0068"],"issn-type":[{"type":"print","value":"2050-0068"},{"type":"electronic","value":"2050-0068"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70050"}}