{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:23:27Z","timestamp":1778199807430,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":321,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clin &amp;amp; Trans Imm"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the first reported case of coexisting Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome and IgG4\u2010related disease (IgG4\u2010RD) and to evaluate the therapeutic response to Upadacitinib.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We described the clinical course, investigations, treatments, and outcomes of a 45\u2010year\u2010old woman initially diagnosed with SAPHO syndrome who subsequently developed IgG4\u2010RD. Laboratory tests, imaging findings, and therapeutic responses were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The patient developed IgG4\u2010RD\u2010related organ involvement during the course of SAPHO syndrome. Although glucocorticoid therapy was initially effective, disease flares occurred upon tapering. Upadacitinib was initiated as an escalation therapy, leading to rapid improvement in clinical symptoms and normalization of inflammatory and IgG4\u2010related serological markers. Sustained remission was maintained with continued treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case demonstrates that Upadacitinib may be an effective therapeutic option for patients with concurrent SAPHO syndrome and IgG4\u2010RD. The observed clinical response supports the potential role of JAK\u2010STAT pathway modulation in managing overlapping immune\u2010mediated disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cti2.70065","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:59:01Z","timestamp":1763513941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Coexistence of SAPHO syndrome and IgG4\u2010related disease with Upadacitinib"],"prefix":"10.1002","volume":"14","author":[{"given":"Hang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Rheumatology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Tangshan Maternal and Child Health Hospital  Tangshan Hebei Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2108-2503","authenticated-orcid":false,"given":"Yi","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Beijing Aerospace General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6014-0635","authenticated-orcid":false,"given":"Yanying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Beijing Friendship Hospital, Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050219-034449"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-023-05491-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003688"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41120"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0633"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X20912865"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1427784"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114760"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1413860"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-0500-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00235"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.70101"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14774"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/mrcr\/rxae047"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X17708940"},{"key":"e_1_2_8_17_1","first-page":"35","article-title":"Serum IgG4 elevation in SAPHO syndrome: does it unmask a disease activity marker?","volume":"38","author":"Li C","year":"2020","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1563542"}],"container-title":["Clinical &amp; Translational Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cti2.70065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:19:44Z","timestamp":1764656384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cti2.70065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":17,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/cti2.70065"],"URL":"https:\/\/doi.org\/10.1002\/cti2.70065","archive":["Portico"],"relation":{},"ISSN":["2050-0068","2050-0068"],"issn-type":[{"value":"2050-0068","type":"print"},{"value":"2050-0068","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70065"}}