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However, mechanistic understanding of the B\u2010cell receptor (BCR) repertoire and its functional impact post\u2010alloHCT remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Within the scope of a mRNA SARS\u2010CoV\u20102 vaccine phase IV clinical trial in alloHCT recipients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200977), we have measured antibody titers and avidity, and performed B\u2010cell immunophenotyping and B\u2010cell receptor repertoire sequencing in sub\u2010populations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AlloHCT patients receiving prime\u2010boost mRNA vaccination within 12\u2009months post\u2010transplant exhibited lower vaccine\u2010specific antibody levels and memory B\u2010cell frequencies than vaccinated healthy controls. Responses were comparable to healthy controls in patients vaccinated later than 12\u2009months post transplant. BCR repertoire sequencing showed reduced somatic hypermutation (SHM) levels in bulk IgG+ B cells from alloHCT patients. Although some alloHCT patients showed exceptional expansion of a few IgG clones of unknown specificity, their overall B\u2010cell repertoires remained polyclonal. Vaccine\u2010specific B\u2010cell clonotypes detected in patients responding to vaccination showed similar proportional expansion and SHM as in controls. The level of immature CD24hiCD38hi transitional B cells pre\u2010vaccination was negatively correlated to the vaccine response, and can be used as a predictor\u00a0of antibody titres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data indicate that mRNA vaccination can stimulate expansion of vaccine\u2010specific B cells to affinity mature in many alloHCT recipients, though restricted by the presence of immature B\u2010cell populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cti2.70077","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:16:36Z","timestamp":1770815796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of B\u2010cell reconstitution on mRNA vaccine responses in allogeneic stem cell transplant 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