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IkappaB\u2010Zeta (I\u03baB\u03b6) is an atypical transcriptional factor of the I\u03baB protein family since, contrary to the other family members, it positively regulates NF\u2010\u03baB pathway by being exclusively localized into the nucleus. I\u03baB\u03b6 deficiency reduces visible manifestations of experimental psoriasis by diminishing expression of psoriasis\u2010associated genes. It is thus tempting to consider I\u03baB\u03b6 as a potential therapeutic target for psoriasis as well as for other IL23\/IL17\u2010mediated inflammatory diseases. 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