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Parkinsonism\u2010associated deglycase (<jats:italic>Park7<\/jats:italic>)\/<jats:italic>Dj1<\/jats:italic> is an important regulator involved in various liver diseases. In nonalcoholic fatty liver diseased mice, induced by a high\u2010fat diet, <jats:italic>Park7<\/jats:italic> deficiency improves hepatic steatosis, but its role in liver regeneration remains unknown<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>Park7<\/jats:italic> knockout (<jats:italic>Park7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup>), hepatocyte\u2010specific <jats:italic>Park7<\/jats:italic> knockout (<jats:italic>Park7<\/jats:italic><jats:sup>\u25b3hep<\/jats:sup>) and hepatocyte\u2010specific <jats:italic>Park7\u2010Pten<\/jats:italic> double knockout mice were subjected to 2\/3 partial hepatectomy (PHx)<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased PARK7 expression was observed in the regenerating liver of mice at 36 and 48\u00a0h after PHx. <jats:italic>Park7<\/jats:italic><jats:sup>\u2212\/\u2212<\/jats:sup> and <jats:italic>Park7<\/jats:italic><jats:sup>\u25b3hep<\/jats:sup> mice showed delayed liver regeneration and enhanced TRAS after PHx. PPARa, a key regulator of \u03b2\u2010oxidation, and carnitine palmitoyltransferase 1a (CPT1a), a rate\u2010limiting enzyme of \u03b2\u2010oxidation, had substantially decreased expression in the regenerating liver of <jats:italic>Park7<\/jats:italic><jats:sup>\u25b3hep<\/jats:sup> mice. Increased phosphatase and tensin homolog (PTEN) expression was observed in the liver of <jats:italic>Park7<\/jats:italic><jats:sup>\u25b3hep<\/jats:sup> mice, which might contribute to delayed liver regeneration in these mice because genomic depletion or pharmacological inhibition of PTEN restored the delayed liver regeneration by reversing the downregulation of PPARa and CPT1a and in turn accelerating the utilization of TRAS in the regenerating liver of <jats:italic>Park7<\/jats:italic><jats:sup>\u25b3hep<\/jats:sup> mice<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Park7<\/jats:italic>\/<jats:italic>Dj1<\/jats:italic> is a novel regulator of PTEN\u2010dependent fatty acid \u03b2\u2010oxidation, and increasing <jats:italic>Park7<\/jats:italic> expression might be a promising strategy to promote liver 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