{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:01:43Z","timestamp":1793826103816,"version":"4.6.1"},"reference-count":150,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011713","name":"Worldwide Cancer Research","doi-asserted-by":"publisher","award":["19\u20100238"],"award-info":[{"award-number":["19\u20100238"]}],"id":[{"id":"10.13039\/100011713","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204804\/Z\/16\/Z"],"award-info":[{"award-number":["204804\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>The Hippo signalling pathway is dysregulated across a wide range of cancer types and, although driver mutations that directly affect the core Hippo components are rare, a handful is found within pleural mesothelioma (PM). PM is a deadly disease of the lining of the lung caused by asbestos exposure. By pooling the largest\u2010scale clinical datasets publicly available, we here interrogate associations between the most prevalent driver mutations within PM and Hippo pathway disruption in patients, while assessing correlations with a variety of clinical markers. This analysis reveals a consistent worse outcome in patients exhibiting transcriptional markers of YAP\/TAZ activation, pointing to the potential of leveraging Hippo pathway transcriptional activation status as a metric by which patients may be meaningfully stratified. Preclinical models recapitulating disease are transformative in order to develop new therapeutic strategies. We here establish an isogenic cell\u2010line model of PM, which represents the most frequently mutated genes and which faithfully recapitulates the molecular features of clinical PM. This preclinical model is developed to probe the molecular basis by which the Hippo pathway and key driver mutations affect cancer initiation and progression. Implementing this approach, we reveal the role of NF2 as a mechanosensory component of the Hippo pathway in mesothelial cells. Cellular NF2 loss upon physiological stiffnesses analogous to the tumour niche drive YAP\/TAZ\u2010dependent anchorage\u2010independent growth. Consequently, the development and characterisation of this cellular model provide a unique resource to obtain molecular insights into the disease and progress new drug discovery programs together with future stratification of PM patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ctm2.1190","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T02:14:25Z","timestamp":1675649665000},"source":"Crossref","is-referenced-by-count":12,"title":["YAP\/TAZ activation predicts clinical outcomes in mesothelioma and is conserved in in vitro model of driver mutations"],"prefix":"10.1002","volume":"13","author":[{"given":"Richard","family":"Cunningham","sequence":"first","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyang","family":"Jia","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna","family":"Purohit","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Salem","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning Sze","family":"Hui","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lin","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil O.","family":"Carragher","sequence":"additional","affiliation":[{"name":"Cancer Research UK Scotland Centre Institute of Genetics and Cancer University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0746-7482","authenticated-orcid":false,"given":"Carsten Gram","family":"Hansen","sequence":"additional","affiliation":[{"name":"Centre for Inflammation Research Institute for Regeneration and Repair Edinburgh BioQuarter University of Edinburgh  Edinburgh UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.145"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3181f1cf2b"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.20360"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.3541"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605781"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6608a3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2021.03.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17186900"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002845"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.09.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.05.020"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-0804"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3520"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32714-8"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S1603"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010021\u201001462\u20102"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2017.42"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-1008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10292"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.06.020"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.333435.119"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1339"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1843810"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1664408"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1602907"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-015-1353-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4550"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3569"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2940"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1212021109"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2191"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00102-15"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24495"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01511.x"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgq254"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2017.5517"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1015"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010022\u201001081\u2010z"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000493"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13071561"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.10.001"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02223.x"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e31829e7ef9"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23837"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2022.04.008"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.025"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.06.015"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201019\u20101704"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI79573"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3562"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.05.002"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2019.10.005"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20201474"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1101\/208660"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2010.10.008"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01139-07"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1054603"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3876"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.037"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.07.005"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.10.034"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2018.11.066"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.140"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8910-2_8"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.189601"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1819400116"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.046755"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0221"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12844"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08966"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.101"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.262816.115"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20200253"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax1738"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-022-00579-x"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2011-100156"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5384"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-371"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1113"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.2174\/15680096113136660102"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4348"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026514"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199442"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.12.043"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0478"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2015.12.006"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2006.08.010"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01292-6"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.05.004"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0300"},{"key":"e_1_2_7_93_1","first-page":"83","article-title":"The role of Hippo pathway in cancer stem cell biology","volume":"41","author":"Park JH","year":"2018","journal-title":"Mol Cells"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014009"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-0874"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010007"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-11-97"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-88390-6"},{"key":"e_1_2_7_99_1","first-page":"2384","article-title":"Suppression of metastasis in human breast carcinoma MDA\u2010MB\u2010435 cells after transfection with the metastasis suppressor gene, KiSS\u20101","volume":"57","author":"Lee JH","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0329"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00115"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1664408"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1094"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-1934-6"},{"key":"e_1_2_7_105_1","first-page":"14","article-title":"STAT3\u2010YAP\/TAZ signaling in endothelial cells promotes tumor angiogenesis","author":"Shen Y","year":"2021","journal-title":"Sci Signal"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14546"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3216"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.67312"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.002"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191035"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201406-240MG"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00588.2003"},{"key":"e_1_2_7_113_1","first-page":"472","article-title":"Behavioral remodeling of normal and cancerous epithelial cell lines with differing invasion potential induced by substrate elastic modulus","volume":"12","author":"Ansardamavandi A","year":"2018","journal-title":"Cell Adh Migr"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.01.005"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2014.03.017"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2011.05.027"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0158-8"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0419-5"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-19-1220"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03668-x"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21798-w"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-018-0048-x"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2005.07.010"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2015.07.015"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.115.2.517"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2122"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.09.009"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.167"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120790"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201806065"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-05-0516"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05939-2"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.08.1264"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.192856.112"},{"key":"e_1_2_7_137_1","first-page":"27","article-title":"Verteporfin inhibits YAP function through up\u2010regulating 14\u20103\u20103\u03c3 sequestering YAP in the cytoplasm","volume":"6","author":"Wang C","year":"2016","journal-title":"Am J Cancer Res"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15614"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0560"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101596"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107809"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4036"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0178-0"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-021-00783-5"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000250"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp1005"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.1190","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.1190","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.1190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T04:03:03Z","timestamp":1692417783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.1190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":150,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/ctm2.1190"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.1190","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]},"article-number":"e1190"}}