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UV is a direct cause of DNA damage, but the mechanisms underlying transcriptional regulation within cells after DNA damage are unclear. The bioinformatics analysis of transcriptome sequencing data from UV\u2010irradiated and non\u2010UV\u2010irradiated skin showed that transcription\u2010related proteins, such as HSF4 and COIL, mediate cellular response to UV irradiation. HSF4 and COIL can form a complex under UV irradiation, and the preference for binding target genes changed because of the presence of a large number of R\u2010loops in cells under UV irradiation and the ability of COIL to recognize R\u2010loops. The regulation of target genes was altered by the HSF4\u2013COIL complex, and the expression of inflammation and ageing\u2010related genes, such as\n                      <jats:italic>Atg7<\/jats:italic>\n                      ,\n                      <jats:italic>Tfpi<\/jats:italic>\n                      , and\n                      <jats:italic>Lims1<\/jats:italic>\n                      , was enhanced. A drug screen was performed for the recognition sites of COIL and R\u2010loop. N6\u2010(2\u2010hydroxyethyl)\u2010adenosine can competitively bind COIL and inhibit the binding of COIL to the R\u2010loop. Thus, the activation of downstream inflammation\u2010related genes and inflammatory skin injury was inhibited.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.1336","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T01:27:12Z","timestamp":1689643632000},"source":"Crossref","is-referenced-by-count":8,"title":["HSF4\/COIL complex\u2010dependent R\u2010loop mediates ultraviolet\u2010induced inflammatory skin injury"],"prefix":"10.1002","volume":"13","author":[{"given":"Yi\u2010qian","family":"Feng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy Nankai University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy Nankai University Tianjin China"},{"name":"Tianjin Key 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