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Bromodomain containing 9 (\n                      <jats:italic>BRD9<\/jats:italic>\n                      ) is a more recently identified protein coding gene, which can encode SWI\/SNF chromatin\u2010remodelling complexes subunits. Although initial evaluations of the potential of BRD9\u2010based targeted therapy have been explored in the clinical application of a small number of cancer types, more detailed study of the diagnostic and prognostic potential, as well as the detailed biological mechanism of\n                      <jats:italic>BRD9<\/jats:italic>\n                      remains unreported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We used various bioinformatics tools to generate a comprehensive, pan\u2010cancer analyses of\n                      <jats:italic>BRD9<\/jats:italic>\n                      expression in multiple disease types described in The Cancer Genome Atlas (TCGA). Experimental validation was conducted in tissue microarrays and cell lines derived from lung and colon cancers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our study revealed that\n                      <jats:italic>BRD9<\/jats:italic>\n                      exhibited elevated expression in a wide range of tumours. Analysis of survival data and DNA methylation for\n                      <jats:italic>BRD9<\/jats:italic>\n                      indicated distinct conclusions for multiple tumours. mRNA splicing and molecular binding were involved in the functional mechanism of\n                      <jats:italic>BRD9<\/jats:italic>\n                      .\n                      <jats:italic>BRD9<\/jats:italic>\n                      may affect cancer progression through different phosphorylation sites or N\n                      <jats:sup>6<\/jats:sup>\n                      \u2010methyladenosine site modifications.\n                      <jats:italic>BRD9<\/jats:italic>\n                      could potentially serve as a novel biomarker for diagnosing different cancer types, especially could accurately forecast the prognosis of melanoma patients receiving anti\u2010programmed cell death 1 immunotherapy.\n                      <jats:italic>BRD9<\/jats:italic>\n                      has the potential to serve as a therapeutic target, when pairing with etoposide in patients with melanoma. The BRD9\/SMARCD1 axis exhibited promising discriminative performance in forecasting the prognosis of patients afflicted with liver hepatocellular carcinoma (LIHC) and mesothelioma. Additionally, this axis appears to potentially influence the immune response in LIHC by regulating the programmed death\u2010ligand 1 immune checkpoint. For experimental validation, high expression levels of BRD9 were observed in tumour tissue samples from both lung and colon cancer patients. Knocking down\n                      <jats:italic>BRD9<\/jats:italic>\n                      led to the inhibition of lung and colon cancer development, likely via the Wnt\/\u03b2\u2010catenin signalling pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These pan\u2010cancer study revealed the diagnostic and prognostic potential, along with the biological mechanism of BRD9 as a novel therapeutic target in human tumours.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.1543","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T02:35:29Z","timestamp":1706841329000},"source":"Crossref","is-referenced-by-count":19,"title":["Pan\u2010cancer analyses of bromodomain containing 9 as a novel therapeutic target reveals its diagnostic, prognostic potential and biological mechanism in human tumours"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1348-8992","authenticated-orcid":false,"given":"Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Quantitative Health Sciences John A. Burns School of Medicine University of Hawaii at Manoa  Honolulu Hawaii USA"},{"name":"Department of Molecular Biosciences and Bioengineering College of Tropical Agriculture and Human Resources Agricultural Sciences University of Hawaii at Manoa  Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zitong","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences John A. Burns School of Medicine University of Hawaii at Manoa  Honolulu Hawaii USA"},{"name":"Department of Molecular Biosciences and Bioengineering College of Tropical Agriculture and Human Resources Agricultural Sciences University of Hawaii at Manoa  Honolulu Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam","family":"Mohd\u2010Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences John A. 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