{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:56:31Z","timestamp":1793534191336,"version":"4.5.0"},"reference-count":119,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T00:00:00Z","timestamp":1709769600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170211"],"award-info":[{"award-number":["82170211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100698"],"award-info":[{"award-number":["32100698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["222300420068"],"award-info":[{"award-number":["222300420068"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M743201"],"award-info":[{"award-number":["2023M743201"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate in tumours, serves as frontline cells in response to tumour progression owing to the rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment a promising field in cancer therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main body<\/jats:title><jats:p>We broadly summarise some studies on the phenotypes and functions of tumour\u2010associated neutrophils as well as the unique web\u2010like products of neutrophils that play a role in cancer progression\u2014neutrophil extracellular traps\u2014and the interactions between neutrophils and the tumour microenvironment. Moreover, several targeted neutrophils therapeutic studies have made some progress and provided potential strategies for the treatment of cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This review aims to offer a holistic perspective on therapeutic interventions targeting neutrophils to further inspire more researches on cancer therapies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ctm2.1599","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T11:13:20Z","timestamp":1709810000000},"source":"Crossref","is-referenced-by-count":34,"title":["Targeting neutrophils: Mechanism and advances in cancer therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7048-8492","authenticated-orcid":false,"given":"Shuaixi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachi","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingshuai","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanbo","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilei","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Zhengzhou University Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.52"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02376"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00571-6"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16022"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.06.017"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.01.006"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0736-z"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.01.002"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-1046"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.05.004"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00012.2018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908576116"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni973"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2004.08.015"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb08237.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2019.01146","article-title":"Tumor associated neutrophils. their role in tumorigenesis, metastasis, prognosis and therapy","volume":"9","author":"Masucci MT","year":"2019","journal-title":"Front Oncol"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00568-5"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3614"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2011.08.012"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557517666170228115324"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14340-w"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2776-8"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.49"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-326070"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01749"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3CE0419-130R"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.02.032"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900543"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.775267"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2908034"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00277"},{"key":"e_1_2_12_36_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147260","article-title":"Neutrophil extracellular traps in colorectal cancer progression and metastasis","volume":"22","author":"Khan U","year":"2021","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84538"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-844530"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12352"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.04.013"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26460-z"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01813-y"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2022.101595"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181170"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28492-5"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02036-z"},{"key":"e_1_2_12_47_1","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14051359","article-title":"Neutrophil extracellular traps in cancer therapy resistance","volume":"14","author":"Shahzad MH","year":"2022","journal-title":"Cancers (Basel)"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30635"},{"key":"e_1_2_12_49_1","article-title":"Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects","volume":"5","author":"Rayes RF","year":"2019","journal-title":"JCI Insight"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701203"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab329"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2084"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2019-2103"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.03.001"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23086-z"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.03.008"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-RW2023-063"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190354"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2018.10.008"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-16-0297"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.12.004"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.10.040"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80006"},{"key":"e_1_2_12_64_1","first-page":"1","article-title":"Lectin\u2010type oxidized LDL receptor\u20101 distinguishes population of human polymorphonuclear myeloid\u2010derived suppressor cells in cancer patients","author":"Condamine T","year":"2016","journal-title":"Sci Immunol"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01530-4"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.13176"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2018.03.009"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-85781-9.00006-3"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6058147"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-221630"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.08.012"},{"key":"e_1_2_12_72_1","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001946","article-title":"Tumor\u2010associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3","volume":"9","author":"Zhou Z","year":"2021","journal-title":"J Immunother Cancer"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010868"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3962"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010224"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.157"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-216085"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21533-5"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31792"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2009.00927.x"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz084"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.1.40"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2008.02018.x"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.05.007"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2021.101583"},{"key":"e_1_2_12_86_1","first-page":"15","article-title":"Circulating and tumor\u2010associated neutrophils in the era of immune checkpoint inhibitors: dynamics, phenotypes, metabolism, and functions","author":"Gibellini L","year":"2023","journal-title":"Cancers (Basel)"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.33594\/000000245"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-302059"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00424-7"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00986-J"},{"key":"e_1_2_12_91_1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041183","article-title":"The impact of hypoxia on neutrophil degranulation and consequences for the host","volume":"21","author":"Lodge KM","year":"2020","journal-title":"Int J Mol Sci"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0054-z"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.007"},{"key":"e_1_2_12_94_1","article-title":"Interleukin 17 signaling supports clinical benefit of dual CTLA\u20104 and PD\u20101 checkpoint inhibition in melanoma","author":"V\u00e1raljai R","year":"2023","journal-title":"Nat Cancer"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-019-1243-8"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcaa012"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11445"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-022-05849-y"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6465"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0880-x"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01315-y"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137345"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2020.08.017"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1700"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/cgt.2016.80"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1716"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.16260"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI131859"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.22946"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-3222"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.12.027"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-44518-8_2"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.016"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cancerbio-030617-050549"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706245"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.04.023"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37872-4"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.04.004"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5513"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14282"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.1599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:56:05Z","timestamp":1715230565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.1599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":119,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ctm2.1599"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.1599","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"article-number":"e1599"}}