{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T02:44:12Z","timestamp":1789267452977,"version":"build-2803163510"},"reference-count":94,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK2573"],"award-info":[{"award-number":["GRK2573"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1292\u2010TP22"],"award-info":[{"award-number":["SFB1292\u2010TP22"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1292\u2010TPQ1"],"award-info":[{"award-number":["SFB1292\u2010TPQ1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GA1818\/2\u20103"],"award-info":[{"award-number":["GA1818\/2\u20103"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>IL\u201017A and TNF synergistically promote inflammation and tumorigenesis. Their interplay and impact on ovarian carcinoma (OC) progression are, however, poorly understood. We addressed this question focusing on mesothelial cells, whose interaction with tumor cells is known to play a pivotal role in transcoelomic metastasis formation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Flow\u2010cytometry and immunohistochemistry experiments were employed to identify cellular sources of IL\u201017A and TNF. Changes in transcriptomes and secretomes were determined by bulk and single cell RNA sequencing as well as affinity proteomics. Functional consequences were investigated by microscopic analyses and tumor cell adhesion assays. Potential clinical implications were assessed by immunohistochemistry and survival analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified Th17 cells as the main population of IL\u201017A\u2010 and TNF producers in ascites and detected their accumulation in early omental metastases. Both IL\u201017A and its receptor subunit IL\u201017RC were associated with short survival of OC patients, pointing to a role in clinical progression. IL\u201017A and TNF synergistically induced the reprogramming of mesothelial cells towards a pro\u2010inflammatory mesenchymal phenotype, concomitantly with a loss of tight junctions and an impairment of mesothelial monolayer integrity, thereby promoting cancer cell adhesion. IL\u201017A and TNF synergistically induced the Th17\u2010promoting cytokines IL\u20106 and IL\u20101\u03b2 as well as the Th17\u2010attracting chemokine CCL20 in mesothelial cells, indicating a reciprocal crosstalk that potentiates the tumor\u2010promoting role of Th17 cells in OC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings reveal a novel function for Th17 cells in the OC microenvironment, which entails the IL\u201017A\/TNF\u2010mediated induction of mesothelial\u2010mesenchymal transition, disruption of mesothelial layer integrity and consequently promotion of OC cell adhesion. These effects are potentiated by a positive feedback loop between mesothelial and Th17 cells. Together with the observed clinical associations and accumulation of Th17 cells in omental micrometastases, our observations point to a potential role in early metastases formation and thus to new therapeutic options.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ctm2.1604","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T06:50:40Z","timestamp":1712127040000},"source":"Crossref","is-referenced-by-count":19,"title":["Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis\u2010associated adhesion of ovarian cancer cells"],"prefix":"10.1002","volume":"14","author":[{"given":"Felix","family":"Neuhaus","sequence":"first","affiliation":[{"name":"Institute of Systems Immunology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"},{"name":"Department of Translational Oncology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Lieber","sequence":"additional","affiliation":[{"name":"Institute of Systems Immunology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Shinkevich","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Mary","family":"Steitz","sequence":"additional","affiliation":[{"name":"Department of Translational Oncology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartmann","family":"Raifer","sequence":"additional","affiliation":[{"name":"Institute of Systems Immunology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"},{"name":"FACS Core Facility Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Roth","sequence":"additional","affiliation":[{"name":"Cell Imaging Core Facility, Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Finkernagel","sequence":"additional","affiliation":[{"name":"Bioinformatics Core Facility, Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Worzfeld","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology Philipps University Marburg Germany"},{"name":"Department of Pharmacology Max Planck Institute for Heart and Lung Research Bad Nauheim Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Burchert","sequence":"additional","affiliation":[{"name":"Department of Hematology Oncology and Immunology University Hospital Giessen and Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Keber","sequence":"additional","affiliation":[{"name":"Comprehensive Biomaterial Bank Marburg (CBBMR) and Institute of Pathology Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Nist","sequence":"additional","affiliation":[{"name":"Genomics Core Facility Institute of Molecular Oncology Member of the German Center for Lung Research (DZL) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Stiewe","sequence":"additional","affiliation":[{"name":"Genomics Core Facility Institute of Molecular Oncology Member of the German Center for Lung Research (DZL) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2851-193X","authenticated-orcid":false,"given":"Silke","family":"Reinartz","sequence":"additional","affiliation":[{"name":"Department of Translational Oncology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-2020","authenticated-orcid":false,"given":"Vanessa M.","family":"Beutgen","sequence":"additional","affiliation":[{"name":"Institute of Translational Proteomics and Translational Proteomics Core Facility Biochemical Pharmacological Centre Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3015-5850","authenticated-orcid":false,"given":"Johannes","family":"Graumann","sequence":"additional","affiliation":[{"name":"Institute of Translational Proteomics and Translational Proteomics Core Facility Biochemical Pharmacological Centre Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Pauck","sequence":"additional","affiliation":[{"name":"Translational Inflammation Research Division and Core Facility for Single Cell Multiomics Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Garn","sequence":"additional","affiliation":[{"name":"Translational Inflammation Research Division and Core Facility for Single Cell Multiomics Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-7772","authenticated-orcid":false,"given":"Matthias","family":"Gaida","sequence":"additional","affiliation":[{"name":"Institute of Pathology University Medical Center Mainz, Johannes Gutenberg University Mainz Germany"},{"name":"TRON, Translational Oncology at the University Medical Center Johannes Gutenberg University Mainz Germany"},{"name":"Research Center for Immunotherapy University Medical Center Mainz, Johannes Gutenberg University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-4248","authenticated-orcid":false,"given":"Rolf","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Translational Oncology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Huber","sequence":"additional","affiliation":[{"name":"Institute of Systems Immunology Center for Tumor Biology and Immunology (ZTI) Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21456"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3432"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00024"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.100105"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2492"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2016.12.005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.633"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-012-9351-2"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8274.CD-11-0010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI74778"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601635"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108401"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.163019"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4889"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2678"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2941"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001136R"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39065"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00792-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00746-9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190297"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327855"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124037"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.03.041"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.537"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-208249"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8797683"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1403424111"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.5428"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abb0192"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200385"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01726"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.165.10.5814"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2013.237"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac385"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8419"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12396"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208943"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-010-9317-0"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1176"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.05.054"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.051222"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_11_46_1","doi-asserted-by":"crossref","unstructured":"BooeshaghiAS ChenX PachterL.A machine\u2010readable specification for genomics assays.bioRxiv2023.","DOI":"10.1101\/2023.03.17.533215"},{"key":"e_1_2_11_47_1","unstructured":"ChenX RoelliP Here\u00f1\u00faD H\u00f6jerP StuartT.2023.https:\/\/doi.org\/10.5281\/zenodo.10042389"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1382-0"},{"key":"e_1_2_11_49_1","unstructured":"McInnesL HealyJ MelvilleJ.Umap: Uniform manifold approximation and projection for dimension reduction.2018.https:\/\/doi.org\/10.48550\/arXiv.1802.03426"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2594"},{"key":"e_1_2_11_51_1","first-page":"26","article-title":"Visualizing High. Dimensional Data Using t\u2010SNE","volume":"9","author":"Maaten LJP","year":"2008","journal-title":"J Mach Learn Res"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1088\/1742-5468\/2008\/10\/P10008"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00490"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2015.12.004"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-023-00742-4"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.37549"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344279"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020809"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2016.11.004"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.09.007"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0237-9"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0674-x"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2023.01.003"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000101304"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095192"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100168"},{"key":"e_1_2_11_68_1","first-page":"3695","article-title":"The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma","volume":"63","author":"Hellstr\u00f6m I","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.01150"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048627"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.02.044"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242741"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710686105"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2020.02.002"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181170"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122311"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1391-0"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1567-0"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-18962-z"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4281"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69815"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061352"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/473134"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022670501667"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00123391"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65406-5"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00121913"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.04.023"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-4887-3"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0117"},{"key":"e_1_2_11_91_1","article-title":"Secukinumab","author":"Aboobacker S","year":"2023","journal-title":"StatPearls"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2291"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.034"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008808"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-0818"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.1604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T13:11:53Z","timestamp":1715173913000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.1604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ctm2.1604"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.1604","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"article-number":"e1604"}}