{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:21:48Z","timestamp":1790572908333,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T00:00:00Z","timestamp":1710806400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF\u20102018R1A2B3001179"],"award-info":[{"award-number":["NRF\u20102018R1A2B3001179"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["NRF\u20102022R1A2C3003496"],"award-info":[{"award-number":["NRF\u20102022R1A2C3003496"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cold ischemia\u2010reperfusion injury (IRI) is an unavoidable complication of kidney transplantation. We investigated the role of regulatory T cells (Treg) in cold IRI and whether the interleukin (IL)\u20102\/anti\u2010IL\u20102 antibody complex (IL\u20102C) can ameliorate cold IRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed a cold IRI mouse model using kidney transplantation and analyzed the IL\u20102C impact on cold IRI in acute, subacute and chronic phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Treg transfer attenuated cold IRI, while Treg depletion aggravated cold IRI. Next, IL\u20102C administration prior to IRI mitigated acute renal function decline, renal tissue damage and apoptosis and inhibited infiltration of effector cells into kidneys and pro\u2010inflammatory cytokine expression on day 1 after IRI. On day 7 after IRI, IL\u20102C promoted renal regeneration and reduced subacute renal damage. Furthermore, on day 28 following IRI, IL\u20102C inhibited chronic fibrosis. IL\u20102C decreased reactive oxygen species\u2010mediated injury and improved antioxidant function. When IL\u20102C was administered following IRI, it also increased renal regeneration with Treg infiltration and suppressed renal fibrosis. In contrast, Treg depletion in the presence of IL\u20102C eliminated the positive effects of IL\u20102C on IRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Tregs protect kidneys from cold IRI and IL\u20102C inhibited cold IRI by increasing the renal Tregs, suggesting a potential of IL\u20102C in treating cold IRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Interleukin (IL)\u20102\/anti\u2010IL\u20102 antibody complex attenuated acute renal injury, facilitated subacute renal regeneration and suppressed chronic renal fibrosis after cold ischemia\u2010reperfusion injury (IRI) by increasing the renal Tregs.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>IL\u20102\/anti\u2010IL\u20102 antibody complex decreased reactive oxygen species\u2010mediated injury and improved antioxidant function.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>This study suggests the therapeutic potential of the IL\u20102\/anti\u2010IL\u20102 antibody complex in kidney transplantation\u2010associated cold IR.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/ctm2.1631","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T06:40:02Z","timestamp":1710916802000},"source":"Crossref","is-referenced-by-count":13,"title":["Interleukin\u20102\/anti\u2010interleukin\u20102 immune complex attenuates cold ischemia\u2010reperfusion injury after kidney transplantation by increasing renal regulatory T cells"],"prefix":"10.1002","volume":"14","author":[{"given":"Joon Young","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6305-452X","authenticated-orcid":false,"given":"Hyung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Jing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Kyeom","family":"Kang","sequence":"additional","affiliation":[{"name":"Natural Product Research Center Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook\u2010Bin","family":"Lee","sequence":"additional","affiliation":[{"name":"Natural Product Research Center Korea Institute of Science and Technology  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5732-2583","authenticated-orcid":false,"given":"Beom Seok","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5378-7797","authenticated-orcid":false,"given":"Jaeseok","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228549"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205034"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2018.01.025"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00098.2004"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17111826"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6665"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.180"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e32835e2a08"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-129"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008111160"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.259"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012080784"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018101067"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010080815"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014060612"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60363"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019060601"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017070774"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.07.019"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1122927"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909384107"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082824"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/108155890405200530"},{"issue":"29","key":"e_1_2_11_25_1","article-title":"Murine renal transplantation procedure","author":"Wang J\u2010J","year":"2009","journal-title":"JoVE"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/127215"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014080813"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84712"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.09.022"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfk047"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040359"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3902"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3410\/M4-1"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019080778"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2019101060"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00533.2018"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12210"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03817.x"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719872699"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03908.x"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003295"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2012.83"},{"key":"e_1_2_11_43_1","first-page":"S54","article-title":"Modulation of T cell responses by IL\u20102 and IL\u20102 complexes","volume":"33","author":"Boyman O","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aba5264"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1214243"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000605"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000424"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014111138"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1531-3"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016050573"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.705838"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0482"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050419"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03847.x"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200002150-00004"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011111130"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0070-2"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.1631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T04:55:52Z","timestamp":1715230552000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.1631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/ctm2.1631"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.1631","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"article-number":"e1631"}}