{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:23:12Z","timestamp":1791498192360,"version":"4.3.4"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"am","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS100801"],"award-info":[{"award-number":["R01NS100801"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201022\u20101\u20100930"],"award-info":[{"award-number":["W81XWH\u201022\u20101\u20100930"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201020\u20101\u20100245"],"award-info":[{"award-number":["W81XWH\u201020\u20101\u20100245"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201016\u20101\u20100497"],"award-info":[{"award-number":["W81XWH\u201016\u20101\u20100497"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2024,4]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post\u2010injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non\u2010neuronal markers or pan\u2010neuronal markers with constitutive expressions.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In animal studies, young adult wildtype and global\n Atf3<\/jats:italic>\n knockout mice underwent unilateral cervical 5 (C5) SCI or permanent distal middle cerebral artery occlusion (pMCAO). Gene expression was assessed using RNA\u2010sequencing and qRT\u2010PCR, while protein expression was detected through immunostaining. Serum ATF3 levels in animal models and clinical human samples were measured using commercially available enzyme\u2010linked immune\u2010sorbent assay (ELISA) kits.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Activating transcription factor 3 (ATF3), a molecular marker for injured dorsal root ganglion sensory neurons in the peripheral nervous system, was not expressed in spinal cord or cortex of na\u00efve mice but was induced specifically in neurons of the spinal cord or cortex within 1 day after SCI or ischemic stroke, respectively. Additionally, ATF3 protein levels in mouse blood significantly increased 1 day after SCI or ischemic stroke. Importantly, ATF3 protein levels in human serum were elevated in clinical patients within 24 hours after SCI or ischemic stroke. Moreover, Atf3 knockout mice, compared to the wildtype mice, exhibited worse neurological outcomes and larger damage regions after SCI or ischemic stroke, indicating that ATF3 has a neuroprotective function.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n ATF3 is an easily measurable, neuron\u2010specific biomarker for clinical SCI and ischemic stroke, with neuroprotective properties.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n \n \n \n ATF3 was induced specifically in neurons of the spinal cord or cortex within 1 day after SCI or ischemic stroke, respectively.<\/jats:p>\n <\/jats:list-item>\n \n Serum ATF3 protein levels are elevated in clinical patients within 24 hours after SCI or ischemic stroke.<\/jats:p>\n <\/jats:list-item>\n \n \n ATF3 exhibits neuroprotective properties, as evidenced by the worse neurological outcomes and larger damage regions observed in\n Atf3<\/jats:italic>\n knockout mice compared to wildtype mice following SCI or ischemic stroke.\n <\/jats:p>\n <\/jats:list-item>\n <\/jats:list>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ctm2.1650","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T23:21:11Z","timestamp":1713828071000},"source":"Crossref","is-referenced-by-count":22,"title":["ATF3 is a neuron\u2010specific biomarker for spinal cord injury and ischaemic stroke"],"prefix":"10.1002","volume":"14","author":[{"given":"Jonathan Z.","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Center for Cerebrovascular Research University of California San Francisco San Francisco California USA"},{"name":"Department of Neurology Cangzhou People's Hospital Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology Shandong Provincial Hospital, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Center for Cerebrovascular Research University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology Shandong Provincial Hospital, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongtao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology Qianfoshan Hospital, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoulin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology The Second Affiliated Hospital, Nanchang University Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amity","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wulin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology Guangzhou Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangliang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Pain Management Xuanwu Hospital, Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-1024","authenticated-orcid":false,"given":"Jacob","family":"Greene","sequence":"additional","affiliation":[{"name":"Medical School University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"An","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology No. 1 People's Hospital Huaian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rich","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Center for Cerebrovascular Research University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Center for Cerebrovascular Research University of California San Francisco San Francisco California USA"},{"name":"Department of Neurosurgery Tianjin Medical University General Hospital Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Kyritsis","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan Duong","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Moncivais","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmeralda","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Fung","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology Shandong Provincial Hospital, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhuan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology Shandong Provincial Hospital, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihang","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology Shandong Provincial Hospital, Shandong University Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Department of Anesthesiology The Second Affiliated Hospital, Dalian Medical University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyuan","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The Second Affiliated Hospital, Dalian Medical University Dalian China"},{"name":"Department of Neurology Hebei Medical University Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Russell","family":"Huie","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Torres\u2010Espin","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam R.","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra D.","family":"Hemmerle","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason F.","family":"Talbott","sequence":"additional","affiliation":[{"name":"Department of Radiology University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip R.","family":"Weinstein","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa U.","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Orthopaedic Trauma Institute University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"DiGiorgio","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Saigal","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Whetstone","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey T.","family":"Manley","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay S.","family":"Dhall","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Harbor UCLA Medical Center Torrance California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline C.","family":"Bresnahan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervyn","family":"Maze","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Center for Cerebrovascular Research University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangning","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neel S.","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Beattie","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery University of California San Francisco San Francisco California USA"},{"name":"Brain and Spinal Injury Center University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"},{"name":"Center for Cerebrovascular Research University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-8370","authenticated-orcid":false,"given":"Zhonghui","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.131797"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010017\u20100858\u2010y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201795"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2018.1428089"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.619721"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393\u2010019\u20100319\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2013.03.012"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30231\u2010X"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7140"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.12b.2083"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2012.00007"},{"key":"e_1_2_10_13_1","first-page":"321","article-title":"ATF3 and stress responses","volume":"7","author":"Hai T","year":"1999","journal-title":"Gene Expr"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460\u20109568.2006.05284.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0814"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5313\u201006.2007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2006.03.005"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.13.5721\u20105732.2004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113273"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.48.4.385"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.36"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153835"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2006.09.006"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0165\u20100270(02)00114\u20100"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.08.026"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780090710"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009234\u20106"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678%D7;21996177"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12817"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.670299"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2014.00116"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68015"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.31.6.507"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2018.0205"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005115"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.255994"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072567"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010017\u20103532\u2010x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102027"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.251335"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2522"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1079338"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.05.002"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.11.054"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/089771503770802899"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230500431368"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2019.18"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2011.11.012"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2085"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100475\u20106"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441\u2010019\u201003039\u20101"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2015.11.030"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(09)70025\u20100"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2017"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2009.10.023"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.2174\/156652408784221315"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000257802.82826.a7"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(02)37006-7"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091418784357"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(96)01387\u2010x"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.11.029"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402060"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5457.1500"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-04-01303.2002"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2020.07.026"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.05.079"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2017.5593"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23723"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314826111"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.06.010"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.1650","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.1650","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T09:10:56Z","timestamp":1715159456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.1650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ctm2.1650"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.1650","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4]]},"article-number":"e1650"}}