{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:36:07Z","timestamp":1790354167062,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The current standard of care for locally advanced gastric cancer (GC) involves neoadjuvant chemotherapy followed by radical surgery. Recently, neoadjuvant treatment for this condition has involved the exploration of immunotherapy plus chemotherapy as a potential approach. However, the efficacy remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single\u2010arm, phase 2 study was conducted to evaluate the efficacy and tolerability of neoadjuvant camrelizumab combined with mFOLFOX6 and identify potential biomarkers of response through multi\u2010omics analysis in patients with resectable locally advanced GC. The primary endpoint was the pathological complete response (pCR) rate. Secondary endpoints included the R0 rate, near pCR rate, progression\u2010free survival (PFS), disease\u2010free survival (DFS), and overall survival (OS). Multi\u2010omics analysis was assessed by whole\u2010exome sequencing, transcriptome sequencing, and multiplex immunofluorescence (mIF) using biopsies pre\u2010 and post\u2010neoadjuvant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This study involved 60 patients, of which 55 underwent gastrectomy. Among these, five (9.1%) attained a pathological complete response (pCR), and 11 (20.0%) reached near pCR. No unexpected treatment\u2010emergent adverse events or perioperative mortality were observed, and the regimen presented a manageable safety profile. Molecular changes identified through multi\u2010omics analysis correlated with treatment response, highlighting associations between HER2\u2010positive and CTNNB1 mutations with treatment sensitivity and a favourable prognosis. This finding was further supported by immune cell infiltration analysis and mIF. Expression data uncovered a risk model with four genes (\n                      <jats:italic>RALYL<\/jats:italic>\n                      ,\n                      <jats:italic>SCGN<\/jats:italic>\n                      ,\n                      <jats:italic>CCKBR<\/jats:italic>\n                      ,\n                      <jats:italic>NTS<\/jats:italic>\n                      ) linked to poor response. Additionally, post\u2010treatment infiltration of CD8+ T lymphocytes positively correlates with pathological response.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings suggest the combination of PD\u20101\u2010inhibitor and mFOLFOX6 showed efficacy and acceptable toxicity for locally advanced GC. Extended follow\u2010up is required to determine the duration of the response. This study lays essential groundwork for developing precise neoadjuvant regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.1674","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:05:12Z","timestamp":1714435512000},"source":"Crossref","is-referenced-by-count":23,"title":["Comprehensive multi\u2010omics analysis of resectable locally advanced gastric cancer: Assessing response to neoadjuvant camrelizumab and chemotherapy in a single\u2010center, open\u2010label, single\u2010arm phase II trial"],"prefix":"10.1002","volume":"14","author":[{"given":"Yuzhou","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pathology The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department 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