{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:51:33Z","timestamp":1792291893717,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new coronavirus SARS\u2010CoV\u20102 has caused outbreaks in multiple countries and the number of cases is rapidly increasing through human\u2010to\u2010human transmission. Clinical phenomes of patients with SARS\u2010CoV\u20102 infection are critical in distinguishing it from other respiratory infections. The extent and characteristics of those phenomes varied depending on the severities of the infection, for example, beginning with fever or a mild cough, progressed with signs of pneumonia, and worsened with severe or even fatal respiratory difficulty in acute respiratory distress syndrome. We summarized clinical phenomes of 3795 patients with COVID\u201019 based on 80 published reports from the onset of outbreak to March 2020 to emphasize the importance and specificity of those phenomes in diagnosis and treatment of infection, and evaluate the impact on medical services. The data show that the incidence of male patients was higher than that of females and the level of C\u2010reaction protein was increased as well as most patients' imaging included ground\u2010glass opacity. Clinical phenomes of SARS\u2010CoV\u20102 infection were compared with those of SARS\u2010CoV and MERS\u2010CoV infections. There is an urgent need to develop an artificial intelligence\u2010based machine learning capacity to analyze and integrate radiomics\u2010 or imaging\u2010based, patient\u2010based, clinician\u2010based, and molecular measurements\u2010based data to fight the outbreak of COVID\u201019 and enable more efficient responses to unknown infections in future.<\/jats:p>","DOI":"10.1002\/ctm2.17","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T14:59:46Z","timestamp":1591714786000},"page":"28-35","source":"Crossref","is-referenced-by-count":23,"title":["Significance of clinical phenomes of patients with COVID\u201019 infection: A learning from 3795 patients in 80 reports"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-7825","authenticated-orcid":false,"given":"Linlin","family":"Zhang","sequence":"first","affiliation":[{"name":"Zhongshan Hospital Institute of Clinical Science Fudan University Shanghai Medical School  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane C.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Sunshine Coast University Hospital  Birtinya Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qihong","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital Institute of Clinical Science Fudan University Shanghai Medical School  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangdong","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhongshan Hospital Institute of Clinical Science Fudan University Shanghai Medical School  Shanghai China"},{"name":"Jinshan Hospital Center for Tumor Diagnosis &amp; Therapy Jinshan Hospital Fudan University Shanghai Medical School  Shanghai China"},{"name":"Shanghai Engineering Research Center of AI Technology for Cardiopulmonary Diseases  Shanghai China"},{"name":"Shanghai Institute of Clinical Bioinformatics  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.69.4.635-664.2005"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2006055"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1143"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2016.08.009"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-020-00271-z"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105924"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.01.009"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001191"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_4_13_1","article-title":"CT imaging of the 2019 novel coronavirus (2019\u2010nCoV) pneumonia","author":"Lei J","year":"2020","journal-title":"Radiology."},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13278"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30251-8"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00114-16"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1107-8"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13021"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fctm2.17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.17","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T14:36:35Z","timestamp":1693665395000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/ctm2.17"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.17","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3]]}}}