{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:19:03Z","timestamp":1772767143565,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mild\u2010moderate psoriasis vulgaris is a common dermatological autoimmune condition with limited conventional therapeutic options. Safe and effective adjunct therapies to topical non\u2010steroidal antipsoriatic therapy are needed. The oral Chinese herbal medicine (CHM) formula PSORI\u2010CM01 has been evidenced potential antipsoriatic pharmacological activity. This article reports a pilot study which was designed as a double\u2010blinded, placebo\u2010controlled randomized controlled trial (RCT) evaluating the effects of PSORI\u2010CM01 when added to topical calcipotriol cream.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>People with moderate psoriasis vulgaris were randomized to receive oral PSORI\u2010CM01 or placebo administered for 12 weeks in combination with calcipotriol. The primary clinical outcome was the change of psoriasis area severity index (PASI) score at week 12 and week 24. Secondary clinical outcomes were PASI75, PASI50, relapse rate, change in body surface area, dermatology life quality index and Skindex29, and adverse events (AEs). Participants\u2019 satisfaction and willingness to repeat were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pilot study was conducted in Australia and China, 29 participants were randomized with 26 completed the treatment and follow\u2010up. Participants\u2019 baseline basic characteristics were comparable. No between\u2010group statistical significance was found on pre\u2010defined clinical outcome measures, although there seemed a trend of treatment effects favoring the combination of PSORI\u2010CM01 with calcipotriol. Frequency and severity of AEs were similar between two groups, with no severe AEs reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The design and duration of the study appears feasible. A proper powered RCT with slight adjustments in the methods is needed to reveal the add\u2010on effects of oral CHM PSORI\u2010CM01. The experience and results from this pilot study will contribute to the refine of objectives and design of a future study, and assist the sample size calculation for the full\u2010scale RCT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ctm2.286","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T23:18:34Z","timestamp":1610752714000},"source":"Crossref","is-referenced-by-count":19,"title":["Add\u2010on effect of PSORI\u2010CM01 to topical calcipotriol for moderate psoriasis vulgaris: A multi\u2010center, randomized, double\u2010blind pilot study"],"prefix":"10.1002","volume":"11","author":[{"given":"Shefton","family":"Parker","sequence":"first","affiliation":[{"name":"China\u2010Australia International Research Centre for Chinese Medicine School of Health and Biomedical Sciences RMIT University  Bundoora Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony 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