{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:11:03Z","timestamp":1791288663696,"version":"4.3.0"},"reference-count":149,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Upper motor neurons (UMNs) are a key component of motor neuron circuitry. Their degeneration is a hallmark for diseases, such as hereditary spastic paraplegia (HSP), primary lateral sclerosis (PLS), and amyotrophic lateral sclerosis (ALS). Currently there are no preclinical assays investigating cellular responses of UMNs to compound treatment, even for diseases of the UMNs. The basis of UMN vulnerability is not fully understood, and no compound has yet been identified to improve the health of diseased UMNs: two major roadblocks for building effective treatment strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Novel UMN reporter models, in which UMNs that are diseased because of misfolded superoxide dismutase protein (mSOD1) toxicity and TDP\u201043 pathology are labeled with eGFP expression, allow direct assessment of UMN response to compound treatment. Electron microscopy reveals very precise aspects of endoplasmic reticulum (ER) and mitochondrial damage. Administration of NU\u20109, a compound initially identified based on its ability to reduce mSOD1 toxicity, has profound impact on improving the health and stability of UMNs, as identified by detailed cellular and ultrastructural analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Problems with mitochondria and ER are conserved in diseased UMNs among different species. NU\u20109 has drug\u2010like pharmacokinetic properties. It lacks toxicity and crosses the blood brain barrier. NU\u20109 improves the structural integrity of mitochondria and ER, reduces levels of mSOD1, stabilizes degenerating UMN apical dendrites, improves motor behavior measured by the hanging wire test, and eliminates ongoing degeneration of UMNs that become diseased both because of mSOD1 toxicity and TDP\u201043 pathology, two distinct and important overarching causes of motor neuron degeneration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Mechanism\u2010focused and cell\u2010based drug discovery approaches not only addressed key cellular defects responsible for UMN loss, but also identified NU\u20109, the first compound to improve the health of diseased UMNs, neurons that degenerate in ALS, HSP, PLS, and ALS\/FTLD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.336","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T04:16:36Z","timestamp":1613967396000},"source":"Crossref","is-referenced-by-count":34,"title":["Improving mitochondria and ER stability helps eliminate upper motor neuron degeneration that occurs due to mSOD1 toxicity and TDP\u201043 pathology"],"prefix":"10.1002","volume":"11","author":[{"given":"Bar\u0131\u015f","family":"Gen\u00e7","sequence":"first","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mukesh","family":"Gautam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6ge","family":"G\u00f6z\u00fctok","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina","family":"Dervishi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santana","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gashaw M.","family":"Goshu","sequence":"additional","affiliation":[{"name":"Department of Chemistry Northwestern University  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuran","family":"Ko\u00e7ak","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Northwestern University  Evanston Illinois USA"},{"name":"Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Center for Developmental Therapeutics Northwestern University  Evanston Illinois USA"},{"name":"Department of Pharmacology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Chemistry of Life Processes Institute Northwestern University  Evanston IL 60208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4125-6013","authenticated-orcid":false,"given":"P. Hande","family":"\u00d6zdinler","sequence":"additional","affiliation":[{"name":"Department of Neurology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Center for Developmental Therapeutics Northwestern University  Evanston Illinois USA"},{"name":"Chemistry of Life Processes Institute Northwestern University  Evanston IL 60208"},{"name":"Mesulam Center for Cognitive Neurology and Alzheimer's Disease Northwestern University, Feinberg School of Medicine  Chicago IL 60611"},{"name":"Les Turner ALS Center Northwestern University, Feinberg School of Medicine  Chicago IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2014.00016"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00363"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0315-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00573"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.233189"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1115-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15265"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41765"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686086"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-15260"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1247363"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15529"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-00434-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-058-8_19"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010715-103548"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104680"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.02.021"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0236-8"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20182042"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3163"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/507423a"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0140316"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.07.017"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30115-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318173ea0b"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2007.11.003"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960600881870"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111592"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00116.x"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960701856300"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00212-4"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1589-y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0896-4"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1934-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.140"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhu318"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.03.036"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00489"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20163848"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.10.014"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.01.027"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0311-0"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.005940"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500045"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00765-w"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21147"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2009.01029.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.64.10.1388"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183684"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.03.066"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-104"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2010.522586"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.11.039"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml3000963"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509201200"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200504050"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2787-12.2013"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908767106"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8209258"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4184-10.2011"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.036"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1039\/9781782620655-00109"},{"key":"e_1_2_11_64_1","first-page":"1","volume-title":"Reviews in Computational Chemistry","author":"Downs GM","year":"2002"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020502"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.06683.x"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw247"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2003.10.004"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.051508.135722"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605210113"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906809106"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00532"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25833"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2652"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820510026162"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.10.013"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00015"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.018"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20413"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4328"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt349"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9631-7"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3121"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.08.017"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.014"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.9.82"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X14666160120152423"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.97152"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140601162710"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.03.024"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.037424"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaq1818"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(97)00247-5"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2017.01.004"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500404b"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-010-9467-1"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880160810"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37968"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0347-y"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3483-14.2015"},{"issue":"7","key":"e_1_2_11_101_1","first-page":"3630","article-title":"Synapse dysfunction of layer V pyramidal neurons precedes neurodegeneration in a mouse model of TDP\u201043 proteinopathies","volume":"27","author":"Handley EE","year":"2017","journal-title":"Cereb Cortex"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.04.025"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304019"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00014-9"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2037-14.2014"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25861"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101972"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3586"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0294-6"},{"key":"e_1_2_11_110_1","first-page":"32","article-title":"Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?","volume":"4","author":"Henriques A","year":"2010","journal-title":"Front Neurosci"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1789"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03381"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.02.002"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2011.06.003"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00199"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2005.07.001"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv631"},{"issue":"4","key":"e_1_2_11_118_1","first-page":"686","article-title":"Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease","volume":"26","author":"Fil D","year":"2017","journal-title":"Hum Mol Genet"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712209105"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022031"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0313-8"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt249"},{"key":"e_1_2_11_123_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.7b00140"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.3109\/17482968.2012.648645"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00336"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1119-12.2013"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.04.053"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4130"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.020"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.06.052"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.99"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0125-1"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-017-0092-6"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.01.008"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00448"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00400"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00073"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2538"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/362059a0"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319386"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1688-8"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801109115"},{"key":"e_1_2_11_143_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22155"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00262"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1159\/000433581"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlx025"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.07.033"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53508-4"},{"key":"e_1_2_11_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.11.021"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2015.07.012"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.336","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.336","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.336","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T16:39:02Z","timestamp":1692376742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":149,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["10.1002\/ctm2.336"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.336","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.739627914.793583462","asserted-by":"object"}]},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2]]},"article-number":"e336"}}