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In the present commentary, we bring to the attention of readers the recent report by Infante et\u00a0al in the journal of clinical and translational medicine. The TERCELOI clinical trial presented the possible paracrine effect of transplanted MSCs <jats:italic>in vitro<\/jats:italic> and i<jats:italic>n vivo<\/jats:italic> using proteomics and transcriptomic analysis. This novel finding adds new knowledge in the field of regenerative medicine. However, the scarcity of solid evidence in growth warrants a more thorough discussion.<\/jats:p>","DOI":"10.1002\/ctm2.385","type":"journal-article","created":{"date-parts":[[2021,4,4]],"date-time":"2021-04-04T17:06:22Z","timestamp":1617555982000},"source":"Crossref","is-referenced-by-count":8,"title":["Trophic effects of multiple administration of mesenchymal stem cells in children with osteogenesis imperfecta"],"prefix":"10.1002","volume":"11","author":[{"given":"Sowmya","family":"Ramesh","sequence":"first","affiliation":[{"name":"Department of Paediatric Orthopaedics Christian Medical College  Vellore Tamil Nadu India"},{"name":"Center for Stem Cell Research, a unit of inStem Bengaluru Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolly","family":"Daniel","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Transfusion Medicine Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"G\u00f6therstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Clinical Science, Intervention &amp; Technology Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-222X","authenticated-orcid":false,"given":"Vrisha","family":"Madhuri","sequence":"additional","affiliation":[{"name":"Department of Paediatric Orthopaedics Christian Medical College  Vellore Tamil Nadu India"},{"name":"Center for Stem Cell Research, a unit of inStem Bengaluru Christian Medical College  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,4]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/6529"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000159029.48678.93"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.132252399"},{"key":"e_1_2_4_5_1","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.00072","article-title":"Mesenchymal stem cells beyond regenerative medicine","volume":"8","author":"Shammaa R","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1050-x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.265"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2013-0090"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0197"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.07.022"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rx.2013.06.001"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3481509"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.3528"},{"key":"e_1_2_4_14_1","first-page":"1","article-title":"The lateral distal femoral DEXA scan in children: a chronology of growing bone?","volume":"31","author":"Tryon E","year":"2008","journal-title":"Orthopedics"},{"key":"e_1_2_4_15_1","unstructured":"LoucksC SzalayE Efficacy of Bisphosphonates in the Treatment of Low Bone Density in the Pediatric Population;2009."},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.091007"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00977"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20215467"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0192-0"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.385","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T01:15:32Z","timestamp":1693617332000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/ctm2.385"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.385","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"article-number":"e385"}}