{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:11:33Z","timestamp":1787235093483,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T00:00:00Z","timestamp":1622937600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hypermetabolism following severe burn injuries is associated with adipocyte dysfunction, elevated beige adipocyte formation, and increased energy expenditure. The resulting catabolism of adipose leads to detrimental sequelae such as fatty liver, increased risk of infections, sepsis, and even death. While the phenomenon of pathological white adipose tissue (WAT) browning is well\u2010documented in cachexia and burn models, the molecular mechanisms are essentially unknown. Here, we report that adipose triglyceride lipase (ATGL) plays a central role in burn\u2010induced WAT dysfunction and systemic outcomes. Targeting adipose\u2010specific ATGL in a murine (AKO) model resulted in diminished browning, decreased circulating fatty acids, and mitigation of burn\u2010induced hepatomegaly. To assess the clinical applicability of targeting ATGL, we demonstrate that the selective ATGL inhibitor atglistatin mimics the AKO results, suggesting a path forward for improving patient outcomes.<\/jats:p>","DOI":"10.1002\/ctm2.417","type":"journal-article","created":{"date-parts":[[2021,6,7]],"date-time":"2021-06-07T09:13:50Z","timestamp":1623057230000},"source":"Crossref","is-referenced-by-count":30,"title":["Adipose\u2010specific ATGL ablation reduces burn injury\u2010induced metabolic derangements in mice"],"prefix":"10.1002","volume":"11","author":[{"given":"Supreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Ross Tilley Burn Centre Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Auger","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Barayan","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Institute of Medical Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyal","family":"Shah","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Matveev","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carly M.","family":"Knuth","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Institute of Medical Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thurl E.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Virginia School of Medicine  Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0870-1664","authenticated-orcid":false,"given":"Marc G.","family":"Jeschke","sequence":"additional","affiliation":[{"name":"Ross Tilley Burn Centre Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"Institute of Medical Sciences University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,6]]},"reference":[{"issue":"10","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1016\/j.bbadis.2017.02.019","article-title":"The biochemical alterations underlying 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