{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:40:21Z","timestamp":1787640021074,"version":"build-2736575974"},"reference-count":148,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several clinical examinations have shown the essential impact of monitoring (de)hydration (fluid and electrolyte imbalance) in cancer patients. There are multiple risk factors associated with (de)hydration, including aging, excessive or lack of fluid consumption in sports, alcohol consumption, hot weather, diabetes insipidus, vomiting, diarrhea, cancer, radiation, chemotherapy, and use of diuretics. Fluid and electrolyte imbalance mainly involves alterations in the levels of sodium, potassium, calcium, and magnesium in extracellular fluids. Hyponatremia is a common condition among individuals with cancer (62% of cases), along with hypokalemia (40%), hypophosphatemia (32%), hypomagnesemia (17%), hypocalcemia (12%), and hypernatremia (1\u20105%). Lack of hydration and monitoring of hydration status can lead to severe complications, such as nausea\/vomiting, diarrhea, fatigue, seizures, cell swelling or shrinking, kidney failure, shock, coma, and even death. This article aims to review the current (de)hydration (fluid and electrolyte imbalance) monitoring technologies focusing on cancer. First, we discuss the physiological and pathophysiological implications of fluid and electrolyte imbalance in cancer patients. Second, we explore the different molecular and physical monitoring methods used to measure fluid and electrolyte imbalance and the measurement challenges in diverse populations. Hydration status is assessed in various indices; plasma, sweat, tear, saliva, urine, body mass, interstitial fluid, and skin\u2010integration techniques have been extensively investigated. No unified (de)hydration (fluid and electrolyte imbalance) monitoring technology exists for different populations (including sports, elderly, children, and cancer). Establishing novel methods and technologies to facilitate and unify measurements of hydration status represents an excellent opportunity to develop impactful new approaches for patient care.<\/jats:p>","DOI":"10.1002\/ctm2.461","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T15:26:35Z","timestamp":1624202795000},"source":"Crossref","is-referenced-by-count":45,"title":["Molecular and physical technologies for monitoring fluid and electrolyte imbalance: A focus on cancer population"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-2608","authenticated-orcid":false,"given":"Devasier","family":"Bennet","sequence":"first","affiliation":[{"name":"Center for Applied NanoBioscience and Medicine The University of Arizona College of Medicine  Phoenix USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasaman","family":"Khorsandian","sequence":"additional","affiliation":[{"name":"Center for Applied NanoBioscience and Medicine The University of Arizona College of Medicine  Phoenix USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody","family":"Pelusi","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute  Scottsdale USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Mirabella","sequence":"additional","affiliation":[{"name":"HonorHealth Research Institute  Scottsdale USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Pirrotte","sequence":"additional","affiliation":[{"name":"Collaborative Center for Translational Mass Spectrometry Translational Genomics Research Institute  Phoenix USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Zenhausern","sequence":"additional","affiliation":[{"name":"Center for Applied NanoBioscience and Medicine The University of Arizona College of Medicine  Phoenix USA"},{"name":"HonorHealth Research Institute  Scottsdale USA"},{"name":"Collaborative Center for Translational Mass Spectrometry Translational Genomics Research Institute  Phoenix USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,20]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/nutrit\/nuv038","article-title":"Acute and chronic effects of hydration status on health","volume":"73","author":"El\u2010Sharkawy AM","year":"2015","journal-title":"Nutr Rev"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.05.007"},{"key":"e_1_2_10_4_1","unstructured":"GomerDR.Staying hydrated during cancer treatment. Conquer;32017."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.08.019"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.44.6518"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2011.06.016"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.069"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8111923"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"80","article-title":"Markers of hydration status","volume":"40","author":"Shirreffs SM","year":"2000","journal-title":"J Sports Med Phys Fitness"},{"key":"e_1_2_10_11_1","unstructured":"UCDavis. Validation of GoBe2TM Hydration Module with Dehydration Induced by Treadmill Exercise. Foods for Health Institute University of California\u2010Davis;2019:1\u20109http:\/\/bit.ly\/ucdavis_validation_hydration. Accessed February 20 2019."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00510A"},{"issue":"2","key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1055\/s-2007-965319","article-title":"Validation of a personal fluid loss monitor","volume":"29","author":"Wickwire J","year":"2008","journal-title":"Int J Sports Med"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.10056"},{"issue":"6","key":"e_1_2_10_15_1","first-page":"817","article-title":"The evaluation of body composition, adiponectin, C\u2010reactive protein and cholesterol levels in patients with obstructive sleep apnea syndrome","volume":"22","author":"Kosacka M","year":"2013","journal-title":"Adv Clin Exp Med"},{"key":"e_1_2_10_16_1","volume-title":"Encyclopedia of Analytical Chemistry","author":"Shaw RA"},{"key":"e_1_2_10_17_1","unstructured":"Devin Warner Miller DRM Inventor. Hydration Monitoring Apparatus. US patent US20140221792A12014."},{"key":"e_1_2_10_18_1","unstructured":"Kenzen Wearable ECHO Smart Patch.https:\/\/www.kenzen.com\/. Accessed May 5 2017."},{"issue":"4","key":"e_1_2_10_19_1","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1152\/jappl.1986.61.4.1410","article-title":"Effect of hydration on plasma volume and endocrine responses to water immersion","volume":"61","author":"Harrison MH","year":"1986","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.2004.01305.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e31820e7cb6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2014.09.012"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.8b04877"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000139797.26760.06"},{"issue":"1","key":"e_1_2_10_25_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41378-019-0067-0","article-title":"A mass\u2010customizable dermal patch with discrete colorimetric indicators for personalized sweat rate quantification","volume":"5","author":"Jain V","year":"2019","journal-title":"Microsystems Nanoengineerng"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cre2.145"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau1749"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.119925"},{"issue":"6","key":"e_1_2_10_29_1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1152\/jappl.1965.20.6.1136","article-title":"Changes in blood plasma during progressive dehydration","volume":"20","author":"Leo C","year":"1965","journal-title":"J Appl Physiol"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.03.033"},{"issue":"4","key":"e_1_2_10_31_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/01.NURSE.0000348406.04065.6d","article-title":"Assessing for dehydration in adults","volume":"39","author":"Rushing J","year":"2009","journal-title":"Nursing"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12637"},{"issue":"11","key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3390\/nu11112689","article-title":"The utility of thirst as a measure of hydration status following exercise\u2010induced dehydration","volume":"11","author":"Adams WM","year":"2019","journal-title":"Nutrients"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00510A"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-015-3099-7"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-009-0982-0"},{"issue":"1","key":"e_1_2_10_37_1","first-page":"53","article-title":"Serum potassium, sodium and calcium levels in healthy individuals: literature review and data analysis","volume":"54","author":"Fijorek K","year":"2014","journal-title":"Folia Med Cracov"},{"issue":"2","key":"e_1_2_10_38_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1159\/000446268","article-title":"Potassium: from physiology to clinical implications","volume":"2","author":"Zacchia M","year":"2016","journal-title":"Kidney Dis(Basel)"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/B978-012396305-5\/50019-1","volume-title":"Clinical Biochemistry of Domestic Animals (5th ed)","author":"Carlson GP","year":"1997"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.010908.163241"},{"key":"e_1_2_10_41_1","volume-title":"StatPearls","author":"Pirahanchi Y","year":"2020"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2006.10.003"},{"issue":"2","key":"e_1_2_10_43_1","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.1111\/j.1753-4887.2008.00105.x","article-title":"Evolution of our understanding of vitamin D","volume":"66","author":"DeLuca HF","year":"2008","journal-title":"Nutr Rev"},{"key":"e_1_2_10_44_1","first-page":"79","article-title":"Electrolyte disorders in cancer patients: a systematic review","volume":"5","author":"Berardi R","year":"2019","journal-title":"J Cancer Metast Treatmnt"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23536"},{"issue":"5","key":"e_1_2_10_46_1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1200\/JCO.1995.13.5.1215","article-title":"Long\u2010term survival in small\u2010cell lung cancer: posttreatment characteristics in patients surviving 5 to 18+ years: an analysis of 1,714 consecutive patients","volume":"13","author":"Lassen U","year":"1995","journal-title":"J Clin Oncol"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2007.762"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0309-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181e63682"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007070752"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc8016"},{"issue":"1","key":"e_1_2_10_52_1","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12904-020-00607-z","article-title":"Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study","volume":"19","author":"Seo MS","year":"2020","journal-title":"BMC Palliat Care"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.5049\/EBP.2020.18.1.16"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003677-200107000-00005"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/166.5.405"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.170600"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.04.025"},{"key":"e_1_2_10_58_1","first-page":"1779","article-title":"Hypercalcemia of malignancy and new treatment options","volume":"11","author":"Sternlicht H","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118947"},{"issue":"2","key":"e_1_2_10_60_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000446694","article-title":"Small cell carcinoma of the ovary (hypercalcemic type): malignant rhabdoid tumor","volume":"9","author":"Kascak P","year":"2016","journal-title":"Case Rep Oncol"},{"issue":"6","key":"e_1_2_10_61_1","first-page":"487","article-title":"Potassium disorders: hypokalemia and hyperkalemia","volume":"92","author":"Viera AJ","year":"2015","journal-title":"Am Fam Physician"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0904569"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506153322407"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2010.03.029"},{"key":"e_1_2_10_65_1","first-page":"376","article-title":"Generalized unresponsiveness to mineralocorticoid hormones: familial recessive pseudohypoaldosteronism due to aldosterone\u2010receptor deficiency","volume":"279","author":"Bosson D","year":"1986","journal-title":"Acta Endocrinol Suppl (Copenh)"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345870660S206"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2017.136"},{"key":"e_1_2_10_68_1","volume-title":"Clinical Methods: The History, Physical, and Laboratory Examinations","author":"Ackerman GL","year":"1990"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14493"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/0736-4679(92)90331-M"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2007.08.016"},{"issue":"6","key":"e_1_2_10_72_1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s00520-002-0358-z","article-title":"Fluid status of terminally ill cancer patients with intestinal obstruction: an exploratory observational study","volume":"10","author":"Morita T","year":"2002","journal-title":"Support Care Cancer"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-003-0486-0"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.11.1022"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0644(05)82375-3"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2008.03.006"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi121"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2005.06.015"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/1865-1380-4-58"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2007.10719661"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1123\/ijsnem.2016-0098"},{"issue":"12","key":"e_1_2_10_82_1","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/ejcn.2013.195","article-title":"Assessment of hydration biomarkers including salivary osmolality during passive and active dehydration","volume":"67","author":"Munoz CX","year":"2013","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181cd9a1d"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.12.142"},{"issue":"12","key":"e_1_2_10_85_1","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1097\/ICO.0b013e31821ddd3a","article-title":"Influence of modest changes in whole\u2010body hydration on tear fluid osmolarity: important considerations for dry eye disease detection","volume":"30","author":"Walsh NP","year":"2011","journal-title":"Cornea"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.12.2686"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/33.1.27"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1391"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.2.649"},{"issue":"1","key":"e_1_2_10_90_1","first-page":"R36","article-title":"Measurement of extracellular space by total body neutron activation","volume":"244","author":"Yasumura S","year":"1983","journal-title":"Am J Physiol"},{"key":"e_1_2_10_91_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/jn\/123.suppl_2.432","article-title":"Body composition and aging: a study by in vivo neutron activation analysis","volume":"123","author":"Heymsfield SB","year":"1993","journal-title":"J Nutr"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/34\/12\/1593"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4904-6"},{"issue":"1","key":"e_1_2_10_94_1","doi-asserted-by":"crossref","first-page":"14771","DOI":"10.1038\/s41598-019-51463-8","article-title":"A portable system to monitor saliva conductivity for dehydration diagnosis and kidney healthcare","volume":"9","author":"Lu Y\u2010P","year":"2019","journal-title":"Sci Rep"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7AY01118K"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2008.09.057"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b02126"},{"issue":"4","key":"e_1_2_10_98_1","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1152\/jappl.1995.79.4.1316","article-title":"Multifrequency bioelectrical impedance estimates the distribution of body water","volume":"79","author":"Cha K","year":"1995","journal-title":"J Appl Physiol (1985)"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.2.269"},{"issue":"1","key":"e_1_2_10_100_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/1471-2407-8-249","article-title":"Bioelectrical impedance phase angle as a prognostic indicator in breast cancer","volume":"8","author":"Gupta D","year":"2008","journal-title":"BMC Cancer"},{"issue":"4","key":"e_1_2_10_101_1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1158\/1055-9965.553.13.4","article-title":"Body size and composition and colon cancer risk in men","volume":"13","author":"MacInnis RJ","year":"2004","journal-title":"Cancer Epidemiology Biomarkers (Prevention)"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-37"},{"issue":"1","key":"e_1_2_10_103_1","first-page":"101","article-title":"Bioimpedance vector pattern in head and neck squamous cell carcinoma","volume":"63","author":"Malecka\u2010Massalska T","year":"2012","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426507022004389"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2008.35"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.7296"},{"issue":"9","key":"e_1_2_10_107_1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/BF00448797","article-title":"Electrical conductivity of tear fluid in healthy persons and keratoconjunctivitis sicca patients measured by a flexible conductimetric sensor","volume":"234","author":"Ogasawara K","year":"1996","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"e_1_2_10_108_1","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0048-9697(88)90141-6","article-title":"Comparison of an inductively coupled plasma\u2010atomic emission spectrometry method for the determination of calcium, magnesium, sodium, potassium, copper and zinc with atomic absorption spectroscopy and flame photometry methods","volume":"74","author":"Dipietro ES","year":"1988","journal-title":"Sci Total Environ"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-0844(200012)18:4<259::AID-CBF881>3.0.CO;2-O"},{"issue":"11","key":"e_1_2_10_110_1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0584-8547(98)00190-6","article-title":"Correction for non\u2010spectroscopic matrix effects in inductively coupled plasma\u2010atomic emission spectroscopy by internal standardization using spectral lines of the same analyte","volume":"53","author":"Al\u2010Ammar AS","year":"1998","journal-title":"Spectrochimica Acta Part B: Atomic Spectroscopy"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000258015.87381.61"},{"issue":"2","key":"e_1_2_10_112_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.4103\/0974-2727.86843","article-title":"Agreement of two different laboratory methods used to measure electrolytes","volume":"3","author":"Albert V","year":"2011","journal-title":"J Lab Physicians"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-015-0522-0"},{"issue":"3","key":"e_1_2_10_114_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1684\/mrh.2013.0346","article-title":"Salivary mineral composition in patients with oral cancer","volume":"26","author":"Dziewulska A","year":"2013","journal-title":"Magnes Res"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510380414"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2000.049"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2016.09.017"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2018.11.024"},{"issue":"11","key":"e_1_2_10_119_1","article-title":"Wireless, flexible, ion\u2010selective electrode system for selective and repeatable detection of sodium","volume":"20","author":"Lim HR","year":"2020","journal-title":"Sensors (Basel)"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00249-016-1173-7"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.990210305"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2017.11.014"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-016-1841-4"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.30.5.708"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/2046-7648-2-4"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2015.06.078"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6LC01450J"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7AN01952A"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf2593"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8LC00530C"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3lc50431j"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300541"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b04225"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201300541"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203133"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2019.103629"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/prca.200900209"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00362"},{"issue":"2","key":"e_1_2_10_139_1","first-page":"308","article-title":"Photoaffinity labeling and purification of ZG\u201016p, a high\u2010affinity dihydropyridine binding protein of rat pancreatic zymogen granule membranes that regulates a K(+)\u2010selective conductance","volume":"57","author":"Braun M","year":"2000","journal-title":"Mol Pharmacol"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.02.020"},{"issue":"7","key":"e_1_2_10_141_1","doi-asserted-by":"crossref","DOI":"10.3390\/metabo9070141","article-title":"Salivary metabolome and soccer match: challenges for understanding exercise induced changes","volume":"9","author":"Pitti E","year":"2019","journal-title":"Metabolites"},{"issue":"1","key":"e_1_2_10_142_1","doi-asserted-by":"crossref","first-page":"15088","DOI":"10.1038\/s41598-019-51492-3","article-title":"Metabolomic profiling identifies novel associations with electrolyte and acid\u2010base homeostatic patterns","volume":"9","author":"Menni C","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"e_1_2_10_143_1","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1074\/mcp.M112.019372","article-title":"High resolution quantitative proteomics of HeLa cells protein species using stable isotope labeling with amino acids in cell culture(SILAC), two\u2010dimensional gel electrophoresis(2DE) and nano\u2010liquid chromatograpohy coupled to an LTQ\u2010OrbitrapMass spectrometer","volume":"12","author":"Thiede B","year":"2013","journal-title":"Mol Cell Proteomics"},{"issue":"2","key":"e_1_2_10_144_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1161\/HYPERTENSIONAHA.118.11733","article-title":"Proteomic landscape of aldosterone\u2010producing adenoma","volume":"73","author":"Swierczynska MM","year":"2019","journal-title":"Hypertension"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-106"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.305"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502011"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.12968\/ijpn.2000.6.8.9060"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.141320"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.461","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.461","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T19:12:16Z","timestamp":1693336336000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":148,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ctm2.461"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.461","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"article-number":"e461"}}