{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:38:03Z","timestamp":1790959083580,"version":"4.1.0"},"reference-count":186,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903032"],"award-info":[{"award-number":["81903032"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M672520"],"award-info":[{"award-number":["2020M672520"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Exosomes are small extracellular vesicles 40\u2013160\u00a0nm in diameter that are secreted by almost all cell types. Exosomes can carry diverse cargo including RNA, DNA, lipids, proteins, and metabolites. Exosomes transfer substances and information between cells by circulating in body fluids and are thus involved in diverse physiological and pathological processes in the human body. Recent studies have closely associated exosomal microRNAs (miRNAs) with various human diseases, including diabetes mellitus (DM), which is a complex multifactorial metabolic disorder disease. Exosomal miRNAs are emerging as pivotal regulators in the progression of DM, mainly in terms of pancreatic \u03b2\u2010cell injury and insulin resistance. Exosomal miRNAs are closely associated with DM\u2010associated complications, such as diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic cardiomyopathy (DCM), etc. Further investigations of the mechanisms of action of exosomal miRNAs and their role in DM will be valuable for the thorough understanding of the physiopathological process of DM. Here, we have summarized recent findings regarding exosomal miRNAs associated with DM to provide a new strategy for identifying potential diagnostic biomarkers and drug targets for the early diagnosis and treatment, respectively, of DM.<\/jats:p>","DOI":"10.1002\/ctm2.468","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T05:31:55Z","timestamp":1624771915000},"source":"Crossref","is-referenced-by-count":225,"title":["Emerging roles of exosomal miRNAs in diabetes mellitus"],"prefix":"10.1002","volume":"11","author":[{"given":"Xiaoyun","family":"He","sequence":"first","affiliation":[{"name":"Departments of Ultrasound Imaging, Xiangya Hospital Central South University  Changsha Hunan 410008 China"},{"name":"Department of Pathology, Xiangya Hospital Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyan","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Hunan University of Chinese Medicine  Changsha Hunan 410007 China"},{"name":"Postdoctoral Research Workstation Hinye Pharmaceutical Co. Ltd  Changsha Hunan 410331 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongrong","family":"Wu","sequence":"additional","affiliation":[{"name":"Hunan university of Chinese Medicine  Changsha Hunan 410208 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-4186","authenticated-orcid":false,"given":"Chunlin","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Xiangya Hospital Central South University  Changsha Hunan 410008 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1605368"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2013.07.004"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.19921"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1414"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.023"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67344-8"},{"issue":"5","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11892-016-0729-3","article-title":"New insights into diabetes cell therapy","volume":"16","author":"Lysy PA","year":"2016","journal-title":"Curr Diab Rep"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13735"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12233"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.05.004"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0689-3"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0619-z"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0823-z"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109716"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0250-9"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009586"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2017.77"},{"issue":"24","key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"11049","DOI":"10.7150\/thno.49168","article-title":"The emerging role of super enhancer\u2010derived noncoding RNAs in human cancer","volume":"10","author":"Wang Y","year":"2020","journal-title":"Theranostics"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.04.011"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12815"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201901380"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2011.76"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1596"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109504"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0959-5"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.28021"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0984-4"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0901-5"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(81)90512-5"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48095-7"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.3.1161"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.009"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.005983"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031594"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/pr8004887"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.3409"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15376"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8678"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201211138"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.125"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2016.10.003"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0985-3"},{"key":"e_1_2_13_45_1","article-title":"Cellular stress conditions are reflected in the protein and RNA content of endothelial cell\u2010derived exosomes","volume":"1","author":"Jong OG","year":"2012","journal-title":"J Extracell Vesicles"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.010"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2005.09.009"},{"issue":"12","key":"e_1_2_13_48_1","doi-asserted-by":"crossref","first-page":"973","DOI":"10.2298\/VSP0912973M","article-title":"Risk factors for coronary heart disease and actual diagnostic criteria for diabetes mellitus","volume":"66","author":"Mitrovic\u2010Perisic N","year":"2009","journal-title":"Vojnosanit Pregl"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25854"},{"issue":"4","key":"e_1_2_13_50_1","first-page":"283","article-title":"Insulin therapy in the elderly with type 2 diabetes","volume":"40","author":"Eriksson JG","year":"2015","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.2337\/db16-1405"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215767111"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0141"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3843"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-015-0097-7"},{"issue":"2","key":"e_1_2_13_56_1","first-page":"2450","article-title":"Bone marrow mesenchymal stem cells\u2010derived exosomal MiR\u201029b\u20103p regulates aging\u2010associated insulin resistance","volume":"13","author":"Su T","year":"2019","journal-title":"ACS Nano"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05043-0"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24805"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2016.09.001"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.010"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01654.x"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.86"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3313"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/161393"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101689"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.12.002"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000603"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00122.2019"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.017"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)61032-X"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.01.007"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0963"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.95"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21365"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3337-2"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0216"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022839"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2011.01.009"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.362632"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0470"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05541-4"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1996"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808855115"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.035"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164114542802"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.305"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.3181\/0705-MR-134"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-017-1779-4"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.06.018"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7932765"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60336-4"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2685305"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0349-y"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0150154"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00166-9"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.88.2.e14"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3980"},{"issue":"10","key":"e_1_2_13_98_1","doi-asserted-by":"crossref","first-page":"e47807","DOI":"10.1371\/journal.pone.0047807","article-title":"Inorganic phosphate accelerates the migration of vascular smooth muscle cells: evidence for the involvement of miR\u2010223","volume":"7","author":"Rangrez AY","year":"2012","journal-title":"PLoS One"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24193"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.112.003905"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/173783"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064558"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-407106"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-02-478925"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2441"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvt013"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12607"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.111.300418"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1113\/EP087396"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1909"},{"issue":"6","key":"e_1_2_13_111_1","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1167\/iovs.15-16498","article-title":"Expression of angiogenic microRNAs in endothelial progenitor cells from type 1 diabetic patients with and without diabetic retinopathy","volume":"56","author":"Garcia DLTN","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814874116"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0454"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0812-9"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0825-4"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6844"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00235"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25617"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1177\/1849454418807827"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v6.i1.37"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1615439"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.11.034"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201904044"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.09.166"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00041.2020"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2016-0275"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9742765"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b00376"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.03.046"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-011-9257-z"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-016-0809-4"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3171-6"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-4397-0_8"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-74470-4_4"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00866.2011"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2014.05.001"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138849"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12589"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2009.12.003"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v8.i9.297"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307654"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.181"},{"key":"e_1_2_13_145_1","doi-asserted-by":"publisher","DOI":"10.2337\/dbi16-0041"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1563"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70065-0"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0504"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2228"},{"issue":"6","key":"e_1_2_13_150_1","first-page":"CD007543","article-title":"Enhanced glucose control for preventing and treating diabetic neuropathy","volume":"6","author":"Callaghan BC","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2239"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2012.07.2576"},{"issue":"12","key":"e_1_2_13_153_1","first-page":"fj201800597R","article-title":"Exosomes derived from high\u2010glucose\u2010stimulated Schwann cells promote development of diabetic peripheral neuropathy","volume":"32","author":"Jia L","year":"2018","journal-title":"FASEB J"},{"key":"e_1_2_13_154_1","doi-asserted-by":"publisher","DOI":"10.2337\/db19-0432"},{"key":"e_1_2_13_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.91"},{"key":"e_1_2_13_156_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-104929"},{"key":"e_1_2_13_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.07.012"},{"key":"e_1_2_13_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.06.005"},{"key":"e_1_2_13_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00070-6"},{"issue":"1","key":"e_1_2_13_160_1","doi-asserted-by":"crossref","first-page":"10900","DOI":"10.1038\/s41598-019-47504-x","article-title":"Differential expression of urinary exosomal microRNAs miR\u201021\u20105p and miR\u201030b\u20105p in individuals with diabetic kidney disease","volume":"9","author":"Zang J","year":"2019","journal-title":"Sci Rep"},{"issue":"5","key":"e_1_2_13_161_1","first-page":"709","article-title":"Potential value of urinary exosome\u2010derived let\u20107c\u20105p in the diagnosis and progression of type ii diabetic nephropathy","volume":"64","author":"Li W","year":"2018","journal-title":"Clin Lab"},{"issue":"6","key":"e_1_2_13_162_1","article-title":"Urinary exosome miR\u2010424 and miR\u2010218 as biomarkers for type 1 diabetes in children","volume":"65","author":"Kong Q","year":"2019","journal-title":"Clin Lab"},{"key":"e_1_2_13_163_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9072184"},{"key":"e_1_2_13_164_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520954763"},{"key":"e_1_2_13_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00177"},{"key":"e_1_2_13_166_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6TB01560C"},{"key":"e_1_2_13_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.12.097"},{"issue":"25","key":"e_1_2_13_168_1","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.7150\/jca.32216","article-title":"Up\u2010regulation of LINC00467 promotes the tumourigenesis in colorectal cancer","volume":"10","author":"He X","year":"2019","journal-title":"J Cancer"},{"key":"e_1_2_13_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.02.005"},{"key":"e_1_2_13_170_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr828"},{"key":"e_1_2_13_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1029"},{"key":"e_1_2_13_172_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky985"},{"key":"e_1_2_13_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2020.103648"},{"key":"e_1_2_13_174_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz042"},{"key":"e_1_2_13_175_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5650"},{"key":"e_1_2_13_176_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx891"},{"key":"e_1_2_13_177_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1107"},{"key":"e_1_2_13_178_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047786"},{"key":"e_1_2_13_179_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CS00174C"},{"key":"e_1_2_13_180_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9TB01490J"},{"key":"e_1_2_13_181_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13361"},{"issue":"1","key":"e_1_2_13_182_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.3390\/ijms22010346","article-title":"Circulating exosomal miRNAs as biomarkers for the diagnosis and prognosis of colorectal cancer","volume":"22","author":"Santos KAD","year":"2020","journal-title":"Int J Mol Sci"},{"key":"e_1_2_13_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2614"},{"key":"e_1_2_13_184_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1521230113"},{"key":"e_1_2_13_185_1","article-title":"Therapeutic strategies for miRNA delivery to reduce hepatocellular carcinoma","author":"Roy B","year":"2021","journal-title":"Semin Cell Dev Biol"},{"key":"e_1_2_13_186_1","doi-asserted-by":"crossref","first-page":"631703","DOI":"10.3389\/fonc.2021.631703","article-title":"Exosomal microRNAs mediating crosstalk between cancer cells with cancer\u2010associated fibroblasts and tumor\u2010associated macrophages in the tumor microenvironment","volume":"11","author":"Su T","year":"2021","journal-title":"Front Oncol"},{"key":"e_1_2_13_187_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408301111"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.468","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T15:12:29Z","timestamp":1693321949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":186,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/ctm2.468"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.468","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"article-number":"e468"}}