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ON is a devastating condition that causes severe pain and compromises the quality of life. The prevalence of ON in SLE patients is variable, ranging from 1.7% to 52%. However, the pathophysiology and risk factors for ON in patients with SLE have not yet been fully determined. Several mechanisms for SLE patients\u2019 propensity to develop ON have been proposed. Glucocorticoid is a widely used therapeutic option for SLE patients and high\u2010dose glucocorticoid therapy in SLE patients is strongly associated with the development of ON. Although the hips and knees are the most commonly affected areas, it may be present at multiple anatomical locations. Clinically, ON often remains undetected until patients feel discomfort and pain at specific sites at which point the process of bone death is already advanced. However, strategies for prevention and options for treatment are limited. Here, we review the epidemiology, risk factors, diagnosis, and treatment options for glucocorticoid\u2010induced ON, with a specific focus on patients with SLE.<\/jats:p>","DOI":"10.1002\/ctm2.526","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:18:23Z","timestamp":1634343503000},"source":"Crossref","is-referenced-by-count":46,"title":["Glucocorticoid\u2010induced osteonecrosis in systemic lupus erythematosus patients"],"prefix":"10.1002","volume":"11","author":[{"given":"Kaichi","family":"Kaneko","sequence":"first","affiliation":[{"name":"Arthritis and Tissue Degeneration Program, David Z. Rosensweig Genomics Research Center Hospital for Special Surgery  New York New York 10021 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Arthritis and Tissue Degeneration Program, David Z. 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