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T cell changes within the tumour microenvironment in AL are poorly understood. By sequencing at a single\u2010cell level of CD3\n                    <jats:sup>+<\/jats:sup>\n                    T cells purified from bone marrow (BM) and blood of newly diagnosed AL patients before and after a combination of daratumumab with cyclophosphamide, bortezomib, and dexamethasone (Dara\u2010BCD), we analysed the transcriptomic features of T cells and found an expansion, activation and type I cytokine upregulation in BM and circulating T cells after the treatment. More prominent changes were shown in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells. In particular, we found the presence of CD8\n                    <jats:sup>+<\/jats:sup>\n                    BM resident memory T cells (T\n                    <jats:sub>RM<\/jats:sub>\n                    ) with high expression of inhibitory molecules in AL patients at diagnosis. 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The similar transcriptomic features of BM and circulating T cells before and after therapy further provide a less invasive approach for molecular monitoring of T cell response in AL amyloidosis.\n                  <\/jats:p>","DOI":"10.1002\/ctm2.582","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T11:39:25Z","timestamp":1638272365000},"source":"Crossref","is-referenced-by-count":6,"title":["T cell landscape and dynamics in immunoglobulin light chain amyloidosis before and after daratumumab\u2010based therapy"],"prefix":"10.1002","volume":"11","author":[{"given":"Yujia","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Immunology School of Basic Medical Sciences Peking University. 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