{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T17:28:09Z","timestamp":1768325289605,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T00:00:00Z","timestamp":1640476800000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1002\/ctm2.646","type":"journal-article","created":{"date-parts":[[2021,12,26]],"date-time":"2021-12-26T16:44:55Z","timestamp":1640537095000},"source":"Crossref","is-referenced-by-count":21,"title":["Deciphering the pathogenic role of a variant with uncertain significance for short QT and Brugada syndromes using gene\u2010edited human\u2010induced pluripotent stem cell\u2010derived cardiomyocytes and preclinical drug screening"],"prefix":"10.1002","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0139-1045","authenticated-orcid":false,"given":"Ibrahim","family":"El\u2010Battrawy","sequence":"first","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"},{"name":"Department of Cardiology and Angiology Bergmannsheil Bochum, Medical Clinic II Ruhr University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Lan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province Institute of Cardiovascular Research, Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Cyganek","sequence":"additional","affiliation":[{"name":"Stem Cell Unit, Clinic for Cardiology and Pneumology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lasse","family":"Maywald","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rujia","family":"Zhong","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering Bioengineering Laboratory  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane","family":"Duperrex","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering Bioengineering Laboratory  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Hierlemann","sequence":"additional","affiliation":[{"name":"Department of Biosystems Science and Engineering Bioengineering Laboratory  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ardan M.","family":"Saguner","sequence":"additional","affiliation":[{"name":"Department of Cardiology Electrophysiology Division University Heart Center Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firat","family":"Duru","sequence":"additional","affiliation":[{"name":"Department of Cardiology Electrophysiology Division University Heart Center Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boldizsar","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Department of Cardiology Electrophysiology Division University Heart Center Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengying","family":"Huang","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxing","family":"Liao","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Albers","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Dinkel","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Rose","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Hohn","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Yang","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Qiao","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingrui","family":"Li","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siegfried","family":"Lang","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Kleinsorge","sequence":"additional","affiliation":[{"name":"Stem Cell Unit, Clinic for Cardiology and Pneumology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Department of Cardiology Electrophysiology Division University Heart Center Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"M\u00fcgge","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Bergmannsheil Bochum, Medical Clinic II Ruhr University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assem","family":"Aweimer","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology Bergmannsheil Bochum, Medical Clinic II Ruhr University  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehui","family":"Fan","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Diecke","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Akin","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province Institute of Cardiovascular Research, Southwest Medical University  Luzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Zhou","sequence":"additional","affiliation":[{"name":"First Department of Medicine Faculty of Medicine University Medical Centre Mannheim (UMM), University of Heidelberg  Mannheim Germany"},{"name":"Key Laboratory of Medical Electrophysiology of Ministry of Education and Medical Electrophysiological Key Laboratory of Sichuan Province Institute of Cardiovascular Research, Southwest Medical University  Luzhou China"},{"name":"DZHK (German Center for Cardiovascular Research) Partner Site Heidelberg\u2010Mannheim and G\u00f6ttingen  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,26]]},"reference":[{"key":"e_1_2_1_4_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.70.1.43"},{"key":"e_1_2_1_4_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.010073"},{"key":"e_1_2_1_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01449-3"},{"key":"e_1_2_1_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2016.11.013"},{"key":"e_1_2_1_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.325"},{"key":"e_1_2_1_4_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8071035"},{"key":"e_1_2_1_4_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908679"},{"key":"e_1_2_1_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1449"},{"key":"e_1_2_1_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz013"},{"key":"e_1_2_1_4_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0420"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.646","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.646","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.646","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T03:48:17Z","timestamp":1693194497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/ctm2.646"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.646","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"article-number":"e646"}}