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Understanding the molecular mechanism of tumour progression and drug resistance will improve therapeutic efficacy and develop novel intervention strategies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Differentially expressed long non\u2010coding RNAs (lncRNAs) in clinical specimens were identified by LncRNA microarrays and validated in different clinical cohorts by quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR), in situ hybridisation and bioinformatics analysis. Biological functions of lncRNA were investigated by using cell proliferation assays, migration assays, xenograft tumour models and bioinformatics analysis. Effects of lncSLCO1C1 on GC cell survival were assessed by comet assays and immunofluorescence assays. Underlying molecular mechanisms were further explored by using a number of technologies including RNA pull\u2010down, mass spectrometry analysis, RNA immunoprecipitation, co\u2010immunoprecipitation, miRNA sequencing, luciferase reporter assays and molecular modelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LncSLCO1C1 was highly upregulated in GC tissue samples and associated with GC patients\u2019 poor overall survival. Overexpression of lncSLCO1C1 promoted proliferation and migration, whereas decreased lncSLCO1C1 expression produced the opposite effects. lncSLCO1C1 also mediated tumour resistance to chemotherapy with oxaliplatin by reducing DNA damage and increasing cell proliferation. Despite sequence overlapping between lncSLCO1C1 and PDE3A, alternations of PDE3A expression had no effect on the GC cell progression, indicating that lncSLCO1C1, not PDE3A, related with the progression of GC cells. Mechanistically, lncSLCO1C1 serves as a scaffold for the structure\u2010specific recognition protein 1 (SSRP1)\/H2A\/H2B complex and regulates the function of SSRP1 in reducing DNA damage. Meanwhile, lncSLCO1C1 functions as a sponge to adsorb miR\u2010204\u20105p and miR\u2010211\u20105p that target SSRP1 mRNA, and thus increases SSRP1 expression. Patients with high expressions of both lncSLCO1C1 and SSRP1 have poor overall survival, highlighting the role of lncSLCO1C1 in GC progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LncSLCO1C1 promotes GC progression by enhancing cell growth and preventing DNA damage via interacting and scaffolding the SSRP1\/H2A\/H2b complex and absorbing both miR\u2010211\u20105p and miR\u2010204\u20105p to increase SSRP1 expression.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ctm2.691","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T03:35:26Z","timestamp":1651030526000},"source":"Crossref","is-referenced-by-count":18,"title":["Role of lncSLCO1C1 in gastric cancer progression and resistance to oxaliplatin therapy"],"prefix":"10.1002","volume":"12","author":[{"given":"Yu\u2010Feng","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Xinqiao Hospital Third Military Medical University  Chongqing 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