{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:44:03Z","timestamp":1793835843811,"version":"4.6.1"},"reference-count":144,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T00:00:00Z","timestamp":1726272000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["21\u201065\u201000004"],"award-info":[{"award-number":["21\u201065\u201000004"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Significant strides have been made in identifying tumour\u2010associated antigens over the past decade, revealing unique epitopes crucial for targeted cancer therapy. Among these, the New York esophageal squamous cell carcinoma (NY\u2010ESO\u20101) protein, a cancer\/testis antigen, stands out. This protein is presented on the cell surface by major histocompatibility complex class I molecules and exhibits restricted expression in germline cells and various cancers, marking it as an immune\u2010privileged site. Remarkably, NY\u2010ESO\u20101 serves a dual role as both a tumour\u2010associated antigen and its own adjuvant, implying a potential function as a damage\u2010associated molecular pattern. It elicits strong humoural immune responses, with specific antibody frequencies significantly correlating with disease progression. These characteristics make NY\u2010ESO\u20101 an appealing candidate for developing effective and specific immunotherapy, particularly for advanced stages of disease. In this review, we provide a comprehensive overview of NY\u2010ESO\u20101 as an immunogenic tumour antigen. We then explore the diverse strategies for targeting NY\u2010ESO\u20101, including cancer vaccination with peptides, proteins, DNA, mRNA, bacterial vectors, viral vectors, dendritic cells and artificial adjuvant vector cells, while considering the benefits and drawbacks of each strategy. Additionally, we offer an in\u2010depth analysis of adoptive T\u2010cell therapies, highlighting innovative techniques such as next\u2010generation NY\u2010ESO\u20101 T\u2010cell products and the integration with lymph node\u2010targeted vaccines to address challenges and enhance therapeutic efficacy. Overall, this comprehensive review sheds light on the evolving landscape of NY\u2010ESO\u20101 targeting and its potential implications for cancer treatment, opening avenues for future tailored directions in NY\u2010ESO\u20101\u2010specific immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Endogenous immune response: NY\u2010ESO\u20101 exhibited high immunogenicity, activating endogenous dendritic cells, T cells and B cells.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NY\u2010ESO\u20101\u2010based cancer vaccines: NY\u2010ESO\u20101 vaccines using protein\/peptide, RNA\/DNA, microbial vectors and artificial adjuvant vector cells have shown promise in enhancing immune responses against tumours.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>NY\u2010ESO\u20101\u2010specific T\u2010cell receptor\u2010engineered cells: NY\u2010ESO\u20101\u2010targeted T cells, along with ongoing innovations in engineered natural killer cells and other cell therapies, have improved the efficacy of immunotherapy.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70020","type":"journal-article","created":{"date-parts":[[2024,9,14]],"date-time":"2024-09-14T05:10:08Z","timestamp":1726290608000},"source":"Crossref","is-referenced-by-count":39,"title":["NY\u2010ESO\u20101 antigen: A promising frontier in cancer immunotherapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Alaa","family":"Alsalloum","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology  Novosibirsk Russia"},{"name":"Faculty of Natural Sciences Novosibirsk State University  Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Shevchenko","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology  Novosibirsk Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7366-7768","authenticated-orcid":false,"given":"Sergey","family":"Sennikov","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology Federal State Budgetary Scientific Institution Research Institute of Fundamental and Clinical Immunology  Novosibirsk Russia"},{"name":"Department of Immunology V. Zelman Institute for Medicine and Psychology Novosibirsk State University  Novosibirsk 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