{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:05:41Z","timestamp":1788282341012,"version":"build-2803163510"},"reference-count":98,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005725","name":"CHDI Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012220","name":"Hercules Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Huntington's disease (HD) is marked by irreversible loss of neuronal function for which currently no availability for disease\u2010modifying treatment exists. Advances in the understanding of disease progression can aid biomarker development, which in turn can accelerate therapeutic discovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We characterised the progression of altered dynamics of whole\u2010brain network states in the zQ175DN mouse model of HD using a dynamic functional connectivity (FC) approach to resting\u2010state fMRI and identified quasi\u2010periodic patterns (QPPs) of brain activity constituting the most prominent resting\u2010state networks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The occurrence of the normative QPPs, as observed in healthy controls, was reduced in the HD model as the phenotype progressed. This uncovered progressive cessation of synchronous brain activity with phenotypic progression, which is not observed with the conventional static FC approaches. To better understand the potential underlying cause of the observed changes in these brain states, we further assessed how mutant huntingtin (mHTT) protein deposition affects astrocytes and pericytes \u2013 one of the most important effectors of neurovascular coupling, along phenotypic progression. Increased cell\u2010type dependent mHTT deposition was observed at the age of onset of motor anomalies, in the caudate putamen, somatosensory and motor cortex, regions that are prominently involved in HD pathology as seen in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings provide meaningful insights into the development and progression of altered functional brain dynamics in this HD model and open new avenues in assessing the dynamics of whole brain states, through QPPs, in clinical HD research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Hyperactivity in the LCN\u2010linked regions within short QPPs observed before motor impairment onset.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>DMLN QPP presents a progressive decrease in DMLN activity and occurrence along HD\u2010like phenotype development.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Breakdown of the LCN DMLN state flux at motor onset leads to a subsequent absence of the LCN DMLN QPP at an advanced HD\u2010like stage.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70055","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T10:50:48Z","timestamp":1729248648000},"source":"Crossref","is-referenced-by-count":8,"title":["Evolution of aberrant brain\u2010wide spatiotemporal dynamics of resting\u2010state networks in a Huntington's disease mouse model"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-3966","authenticated-orcid":false,"given":"Tamara","family":"Vasilkovska","sequence":"first","affiliation":[{"name":"Bio\u2010Imaging Lab University of Antwerp Wilrijk Antwerp Belgium"},{"name":"\u00b5NEURO Research Centre of Excellence University of Antwerp Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Verschuuren","sequence":"additional","affiliation":[{"name":"\u00b5NEURO Research Centre of Excellence University of Antwerp Antwerp Belgium"},{"name":"Laboratory of Cell Biology and Histology University of Antwerp Wilrijk Antwerp Belgium"},{"name":"Antwerp Centre for Advanced Microscopy University of Antwerp Wilrijk Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorian","family":"Pustina","sequence":"additional","affiliation":[{"name":"CHDI Management, Inc. for CHDI Foundation, Inc. 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