{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:21:03Z","timestamp":1793089263825,"version":"4.5.0"},"reference-count":213,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Acute lung injury (ALI)\/acute respiratory distress syndrome (ARDS) is a severe respiratory condition associated with elevated morbidity and mortality. Understanding their complex pathophysiological mechanisms is crucial for developing new preventive and therapeutic strategies. Recent studies highlight the significant role of inflammation involved in ALI\/ARDS, particularly the hyperactivation of the NOD\u2010like receptor thermal protein domain\u2010associated protein 3 (NLRP3) inflammasome in macrophages. This activation drives pulmonary inflammation by releasing inflammatory signalling molecules and is linked\u00a0to metabolic reprogramming, marked by increased glycolysis and reduced oxidative phosphorylation. However, the relationship between NLRP3 inflammasome activation and macrophage glycolytic reprogramming in ALI\/ARDS, as well as the molecular mechanisms regulating these processes, remain elusive. This review provides a detailed description of the interactions and potential mechanisms linking NLRP3 inflammasome activation with macrophage glycolytic reprogramming, proposing that glycolytic reprogramming may represent a promising therapeutic target for mitigating inflammatory responses in ALI\/ARDS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>NLRP3 inflammasome activation is pivotal in mediating the excessive inflammatory response in ALI\/ARDS.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Glycolytic reprogramming regulates NLRP3 inflammasome activation.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>Therapeutic potential of targeting glycolytic reprogramming to inhibit NLRP3 inflammasome activation in ALI\/ARDS.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p><\/jats:sec>","DOI":"10.1002\/ctm2.70098","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T07:41:37Z","timestamp":1733211697000},"source":"Crossref","is-referenced-by-count":35,"title":["The role of the interplay between macrophage glycolytic reprogramming and NLRP3 inflammasome activation in acute lung injury\/acute respiratory distress syndrome"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7029-4129","authenticated-orcid":false,"given":"Lan","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Extracorporeal Circulation and Mechanical Circulation Assistants Center for Cardiac Intensive Care Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Extracorporeal 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