{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:19:54Z","timestamp":1787242794240,"version":"build-2736575974"},"reference-count":226,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T00:00:00Z","timestamp":1754784000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA217842"],"award-info":[{"award-number":["U01CA217842"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01CA217842"],"award-info":[{"award-number":["U01CA217842"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RR170048"],"award-info":[{"award-number":["RR170048"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Lung cancer remains the leading cause of cancer\u2010related death in both women and men in the United States and globally. Even among early\u2010stage patients who undergo surgical resection, a significant portion of patients develop metastases. Notably, approximately 30% of patients with stage I lung cancer experience relapse. For decades, protein\u2010coding genes dominated cancer research, driven by the belief that these genes were the primary contributors to tumorigenesis. Despite advances in treatment our understanding of fundamental mechanismsdriving lung cancer progression remains limited. The overall 5\u2010year survival rate for all stages of lung cancer combined is approximately 20%. Surgical resection remains the best option for early\u2010stage diseases, whereas chemotherapy, immunotherapy or combination therapies are primarily employed in advanced stages. Frequent treatment failure due to therapy resistance, highlight the urgent need to identify novel biomarkers for early diagnosis, prognosis, and the development of more effective therapies. This underscores the necessity and urgency of researching lncRNAs. The advent of next\u2010generation sequencing and other high\u2010throughput technologies guided the discovery of a new class of molecules, non\u2010coding RNAs (ncRNAs) that play a role in many aspects of cellular physiology. Among the various types of ncRNAs, long non\u2010coding RNAs (lncRNAs)\u2014which have transcripts longer than 200 nucleotides\u2014have emerged as key regulatory molecules in a myriad of cell functions by interacting with DNA, with other RNAs, including mRNA, miRNA and with proteins. Importantly, lncRNAs play crucial roles in cancer progression, including metastasis by activating oncogenic pathways, promoting epithelial\u2010mesenchymal transition, remodelling the extracellular matrix, and inducing angiogenesis. Notably, they can function as both oncogenes and tumour suppressors.\n                      <jats:italic>MALAT1<\/jats:italic>\n                      is one of the lncRNAs that contribute to metastasis and resistance to tyrosine kinase inhibitors in lung cancer. This review summarizes the role of lncRNAs in cancer, with a specific emphasis on their contributions to lung cancer metastasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>LncRNAs are significant players in lung cancer metastasis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LncRNAs can be used as therapeutic target in lung cancer.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>LncRNAs can be used as prognostic factors in lung cancer.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Exosomal lncRNAs can be used to predict prognosis in lung cancer.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70429","type":"journal-article","created":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T07:18:47Z","timestamp":1754810327000},"source":"Crossref","is-referenced-by-count":11,"title":["The role of long non\u2010coding RNAs in lung cancer metastasis: Molecular mechanisms, pathogenesis and clinical implications"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5412-7117","authenticated-orcid":false,"given":"Musaffe","family":"Tuna","sequence":"first","affiliation":[{"name":"Department of Medicine Baylor College of Medicine  Houston USA"},{"name":"Institute of Clinical and Translational Research Baylor College of Medicine  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon B","family":"Mills","sequence":"additional","affiliation":[{"name":"Division of Oncological Sciences Oregon Health Science University  Portland USA"},{"name":"Knight Cancer Institute Oregon Health Science University  Portland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Amos","sequence":"additional","affiliation":[{"name":"Department of Medicine Baylor College of Medicine  Houston USA"},{"name":"Institute of Clinical and Translational Research Baylor College of Medicine  Houston USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.109231"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.043"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac087"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02990-6"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0182"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0369"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14944"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox077"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.02.016"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2012-13-9-r51"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-060614-034258"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040022"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.10.1.28"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13274"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-10-38"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02113-y"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-19-0564"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1247\/csf.18005"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.03.013"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz646"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.09.015"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1621\/nrs.05006"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/trns.1.3.13332"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199711)183:3<345::AID-PATH930>3.0.CO;2-8"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.07.033"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.14.3617"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.10.007"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.07.003"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2017.10.004"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.132159.111"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.03.050"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.12.012"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1164096"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1416106"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1138341"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-014-2093-4"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2014.35"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.022"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw047"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.02.006"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-051410-092902"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008930"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25757"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00315-9"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.006"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_12_50_1","first-page":"39","article-title":"A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains","volume":"8","author":"Hutchinson JN","year":"2007","journal-title":"Bmc Genomics [Electronic Resource]"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky046"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.05.013"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2221109120"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2014-15-1-r6"},{"issue":"1","key":"e_1_2_12_55_1","first-page":"414","article-title":"Identification and analysis of ribosome\u2010associated lncRNAs using ribosome profiling data","volume":"19","author":"Zeng C","year":"2018","journal-title":"Bmc Genomics [Electronic Resource]"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-62836-z"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00325-z"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0017-y"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300314"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2022.08.004"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0143-4"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2018.08.005"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1160809"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna3010010"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.10.039"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-0605"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26740"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.06.031"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0066-7"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcab002"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2019.84.039404"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.08.018"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03633-w"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.351913.124"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.168"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28882"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.013"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2016.110"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.08.018"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0426-x"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0685-9"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1107-y"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26021"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36713-8"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14727"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.851004"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3673"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.07.050"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.011"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228110"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02200"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1991"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1933744100"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2010.199"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.028639.111"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.08.011"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.01.015"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2085"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12787"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature21374"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0113-5"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0729-1"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12970-4"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.025"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002521"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2020.118837"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.69210"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2019-0435"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01276-y"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.06.008"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24099-4"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206928"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0931430100"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13057"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20437"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12634"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.04.020"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.08.021"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2710"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.14131"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddae176"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.119"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2010.02.009"},{"issue":"7","key":"e_1_2_12_124_1","first-page":"1475","article-title":"Monoallelic up\u2010regulation of the imprinted H19 gene in airway epithelium of phenotypically normal cigarette smokers","volume":"63","author":"Kaplan R","year":"2003","journal-title":"Cancer Res"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2014.06.020"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.01.003"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1067"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.02.002"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15214"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.488593"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.055830.115"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu103"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04304-4"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01421-w"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22919"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0472-6"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-1133-9"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-021-01760-2"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-020-0217-0"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2371-0"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34396"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.09.022"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.10.012"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643370"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.206854"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-1508"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.01.015"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-2850"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-021-00649-8"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.484"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-0356"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.08.057"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2376"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11661"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12791"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1361-3"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216826"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2025.2510041"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00598-y"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03147-9"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12181"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0645-x"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0722-8"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1129"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02331-0"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67325-7"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00562-y"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0836-7"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2409-0"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-0671"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7077"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.101"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-464"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182307eac"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01217-2"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0984-2"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16158"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0842-2"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.11.024"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03259-2"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1811-y"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01469-6"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03928-w"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23367"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00613-x"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-022-00831-6"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.14854"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-03198-y"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18280-3"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-13-68"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2022.01.031"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01705-7"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1752"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11630"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.062"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.01.023"},{"issue":"3","key":"e_1_2_12_197_1","first-page":"270","article-title":"LncRNA MALAT1 depressed chemo\u2010sensitivity of NSCLC cells through directly functioning on miR\u2010197\u20103p\/p120 catenin axis","volume":"42","author":"Yang T","year":"2019","journal-title":"Mol Cells"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4361"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10521"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20475"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-020-04152-7"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.06.037"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.11.75"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.123"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.56093"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16562"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S146423"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2022.100171"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002746"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27235"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2022.09.016"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c02260"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl1071"},{"issue":"3","key":"e_1_2_12_214_1","article-title":"Challenges of CRISPR\/Cas9 applications for long non\u2010coding RNA genes","volume":"45","author":"Goyal A","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10006"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2016.11.009"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.14"},{"issue":"6","key":"e_1_2_12_218_1","first-page":"2307","article-title":"Loss of MEG3 contributes to the enhanced migration and invasion in arsenic\u2010induced carcinogenesis through NQO1\/FSCN1 pathway","volume":"13","author":"Tu H","year":"2023","journal-title":"Am J Cancer Res"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2016.05.012"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2021.115845"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.26263"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201211138"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2010.06.006"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4763"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02859-y"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13216"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.02.141"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.70429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T04:44:08Z","timestamp":1773981848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.70429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":226,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/ctm2.70429"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.70429","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"e70429"}}