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Furthermore, we found that \u03b2\u2010elemene enhances imatinib sensitivity in imatinib\u2010resistant GIST cells through inducing ferroptosis. Moreover, the combination treatment of \u03b2\u2010elemene and imatinib showed significantly increased antitumour efficacy, compared to each monotherapy, both in vitro and in vivo. Mechanistically, \u03b2\u2010elemene specifically targets N6AMT1, inhibiting its transcriptional repression function and activating the nuclear factor erythroid 2\u2010related factor 2 (NRF2)\u2010HMOX1 signalling pathway to induce ferroptosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\u0392\u2010elemene can target N6AMT1 and promote ferroptosis by increasing the expression of NRF2 and HMOX1. These findings suggest \u03b2\u2010elemene as a prospective therapeutic strategy to improve the sensitivity of imatinib in gastrointestinal stromal tumours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>l Imatinib resistance is associated with ferroptosis activity in GIST.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>l Combination of \u03b2\u2010elemene and imatinib effectively treats gastrointestinal stromal tumours both in vivo and in vitro.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>l \u03b2\u2010elemene promotes imatinib sensitivity in GIST through ferroptosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>l N6AMT1 is a potential target of \u03b2\u2010elemene.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>l \u03b2\u2010elemene targets N6AMT1 to promote imatinib sensitivity in imatinib\u2010resistant GIST cells via the NRF2\/HMOX1 axis.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70438","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T03:27:28Z","timestamp":1756351648000},"source":"Crossref","is-referenced-by-count":3,"title":["\u03b2\u2010elemene promotes ferroptosis to improve the sensitivity of imatinib in gastrointestinal stromal tumours by targeting 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