{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:56:08Z","timestamp":1790520968320,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023B1515040016"],"award-info":[{"award-number":["2023B1515040016"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ulcerative colitis (UC) is an agnogenic chronic intestinal inflammatory disease. Umbilical cord\u2010derived mesenchymal stem cell (UMSC) is a potential therapeutic approach against UC; however, the mechanisms underlying their efficacy for UC remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010arm clinical trial with 6 months follow\u2010up to assess the efficacy of UMSC in patients with moderate to severe left\u2010sided UC. The 26 enrolled patients were administered two UMSC doses intravenously. Pre\u2010 and post\u2010therapy colon biopsy specimens were analysed by single\u2010cell RNA sequencing (scRNA\u2010seq). Dextran sulphate sodium (DSS)\u2010induced colitis mouse models with or without UMSC injection were used to delineate colon inflammation and T cell function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the clinical trial, the clinical response\/remission rates were 80.8\/46.2% and 75.0\/37.5% after 2 and 6 months of therapy, respectively. Endoscopic and histological examinations showed improvement of colonic mucosa after UMSC therapy in responders. scRNA\u2010seq data showed that UMSC therapy may suppress pro\u2010inflammatory features of T lymphocytes and alleviate inflammatory responses by inhibiting the interaction of T cells with B and myeloid cells. In the murine experiment, UMSCs suppressed DUOX2\u2010mediated oxidative stress to attenuate DSS\u2010induced colitis by regulating T cell\u2010mediated immunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>UMSC therapy primarily modulates T cell\u2010mediated immunity to achieve gut mucosal immune reconstitution and maintain mucosal barrier integrity, thereby achieving effective UC recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>UMSCs effectively induce clinical remission in patients with active UC via T cell\u2010mediated immune reconstitution.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>scRNA\u2010seq analyses further revealed that UMSC therapy suppressed pro\u2010inflammatory features of T cells and alleviated inflammatory responses by inhibiting the interaction of T cells with B and myeloid cells<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>UMSCs suppressed DUOX2\u2010mediated oxidative stress to attenuate DSS\u2010induced colitis by regulating T cell\u2010mediated immunity.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70452","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T06:55:28Z","timestamp":1755845728000},"source":"Crossref","is-referenced-by-count":8,"title":["Reconstitution of T cell\u2010mediated immunity by umbilical cord\u2010derived mesenchymal stem cells in ulcerative colitis"],"prefix":"10.1002","volume":"15","author":[{"given":"Xiaoying","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou University  Zhengzhou China"},{"name":"Department of Microbiome Laboratory Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou University Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieping","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Systems Biomedical Sciences School of Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0439-2879","authenticated-orcid":false,"given":"Xiaoke","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Mi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqiu","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou University  Zhengzhou 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