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However, within the tumour microenvironment (TME), this process is systematically hijacked by tumour cells, transforming it into a key pathological mechanism that drives immunosuppression, tumour progression and therapeutic resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key findings<\/jats:title>\n                    <jats:p>This review systematically elucidates the central role of metabolic reprogramming in this functional reversal, emphasising that efferocytosis is essentially an immunometabolic intersection process precisely regulated by metabolism. By releasing various metabolites such as ATP, lactate, adenosine and sphingosine\u20101\u2010phosphate (S1P), apoptotic tumour cells not only recruit tumour\u2010associated macrophages (TAMs) but also metabolically pre\u2010program their functions, inducing polarisation towards a pro\u2010tumourigenic M2\u2010like phenotype. During the recognition stage, tumour cells exploit metabolic abnormalities, such as glycosylation and lipid oxidation, to modify surface \u2018eat\u2010me\/don't\u2010eat\u2010me\u2019 signals, thereby hijacking macrophage recognition and engulfment programs. Upon completion of engulfment, systemic reprogramming of amino acid, lipid and glucose metabolism occurs within macrophages. These metabolic alterations synergistically lock their immunosuppressive phenotype and establish a metabolic symbiosis between the tumour and stromal cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on these mechanisms, this review further explores translational strategies targeting the efferocytic\u2013metabolic axis, aiming to reprogram the immunosuppressive efferocytosis into immune\u2010activating events to overcome TME\u2010mediated immunosuppression and enhance current therapeutic efficacy. By deeply dissecting the metabolic regulatory networks of efferocytosis, we aim to pave new directions for cancer immunotherapy, achieving a paradigm shift from \u2018metabolic hijacking\u2019 to \u2018metabolic interventional therapy\u2019.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70601","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T09:08:04Z","timestamp":1769591284000},"source":"Crossref","is-referenced-by-count":10,"title":["Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic\u2010cell clearance to therapeutic targeting"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5496-3712","authenticated-orcid":false,"given":"Qianlu","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Breast Surgery of the Third Affiliated Hospital of Kunming Medical University Yunnan Cancer Hospital, Peking University Cancer Hospital Yunnan  Kunming 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