{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:21:34Z","timestamp":1792448494980,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070358"],"award-info":[{"award-number":["82070358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770430"],"award-info":[{"award-number":["81770430"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170423"],"award-info":[{"award-number":["82170423"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical & Translational Med"],"published-print":{"date-parts":[[2026,2]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n C1q\/TNF\u2010related proteins (CTRPs) belong to the adipokine family. Here, we aimed to assess the relation of CTRP4 levels in serum and perivascular adipose tissue (PVAT) with coronary artery disease (CAD), and investigate the effect of CTRP4 on atherosclerosis and the underlying mechanisms.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n CTRP4 levels were examined in serum and epicardial adipose tissue (a major PVAT) from patients with CAD. Atherosclerotic lesions were analysed in CTRP4\n \u2012\/\u2012<\/jats:sup>\n \/ApoE\n \u2012\/\u2012<\/jats:sup>\n and ApoE\n \u2012\/\u2012<\/jats:sup>\n mice. The paracrine effects of CTRP4 on atherosclerosis were tested by supplementation with CTRP4, either via PVAT transplantation or tail vein injection in CTRP4\n \u2212\/\u2212<\/jats:sup>\n \/ApoE\n \u2212\/\u2212<\/jats:sup>\n mice. CTRP4\u2010interacting proteins were identified using immunoprecipitation and mass spectrometry.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n CTRP4 levels were lower in serum and epicardial adipose tissue of patients with CAD compared to non\u2010CAD controls. CTRP4 knockout promoted atherosclerosis in ApoE\n \u2012\/\u2012<\/jats:sup>\n mice. Supplementation of CTRP4, but not receptor for advanced glycation end\u2010products (RAGE)\u2010 and toll\u2010like receptor 4 (TLR4)\u2010binding incompetent CTRP4 mutant, either through adipose tissue transplantation from wild\u2010type mice or intravenous injection of recombinant protein, attenuated atherosclerosis in CTRP4\n \u2012\/\u2012<\/jats:sup>\n \/ApoE\n \u2012\/\u2012<\/jats:sup>\n mice. In macrophages, CTRP4 protein, but not the mutant, suppressed the expression of lipopolysaccharide\u2010induced inflammatory cytokines. Mechanistically, the anti\u2010atherogenic effects of CTRP4 were mediated by the engagement and inhibition of RAGE and TLR4.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Decreased CTRP4 levels in serum and epicardial adipose tissue are associated with CAD in patients. CTRP4 deficiency promotes the development of atherosclerosis in ApoE\n \u2012\/\u2012<\/jats:sup>\n mice, whereas CTRP4 supplementation attenuates atherosclerosis via binding and inhibition of RAGE and TLR4. These results suggest that CTRP4 is a novel anti\u2010inflammatory and anti\u2010atherogenic adipokine inversely associated with CAD and a potential therapeutic target.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/ctm2.70624","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T09:21:25Z","timestamp":1771406485000},"source":"Crossref","is-referenced-by-count":1,"title":["Decreased adipokine CTRP4 in CAD patients: CTRP4 attenuates atherosclerosis via inhibition of RAGE and TLR4"],"prefix":"10.1002","volume":"16","author":[{"given":"Xinyi","family":"Shu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai P.R. China"},{"name":"Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine Shanghai P.R. 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