{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:10:30Z","timestamp":1774429830286,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Patients undergoing multiple wound repair surgeries often develop moderate\u2010to\u2010severe anxiety and depression. However, there is a lack of effective rapid emotional intervention strategies during the perioperative period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi\u2010centre, randomized, double\u2010blind, placebo\u2010controlled trial involved 130 adult patients (65 in the esketamine group and 65 in the placebo group). Participants were randomly assigned to receive either esketamine (0.2\u20130.3\u00a0mg\/kg) or saline intravenously during surgery. The primary outcome was the response rate (proportion of patients with \u226550% reduction in MADRS total score from baseline) on postoperative days (PODs) 1\u20133, evaluated using the Montgomery\u2013\u00c5sberg depression rating scale (MADRS). The secondary outcome was the remission rate (proportion of patients with MADRS total score \u226410) on postoperative days (PODs) 1\u20133; scores on the Patient Health Questionnaire\u20109 (PHQ\u20109), the Hospital Anxiety and Depression Scale\u2010Anxiety subscale (HADS\u2010A); and esketamine\u2010related neuropsychiatric adverse events assessed using the Young Mania Rating Scale (YMRS), Clinician\u2010Administered Dissociative States Scale (CADSS), and Brief Psychiatric Rating Scale (BPRS) within 30 days after surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The esketamine group showed a significantly higher response rate than the placebo group on POD 1\u20133. (POD 1: 53.8%\u00a0vs. 26.2%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.001; POD 2: 60.0%\u00a0vs. 40.0%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.009; POD 3: 73.8%\u00a0vs. 53.8%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.018). The esketamine group also showed a higher remission rate and lower MADRS scores (POD 1: 33.8%\u00a0vs. 10.8%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.002; POD 2: 40.0%\u00a0vs. 23.1%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      =\u00a00.038; POD 3: 56.9%\u00a0vs. 23.1%,\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). Esketamine improved HADS\u2010A and PHQ\u20109 scores by POD 3 without increasing neuropsychiatric adverse events within 30 days postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results demonstrate that the intraoperative use of low\u2010dose esketamine can rapidly and effectively alleviate moderate\u2010to\u2010severe anxiety and depressive symptoms in the early postoperative period (POD 1\u20133) among patients requiring repeated debridement surgeries without increasing neuropsychiatric or systemic adverse events within 30 days after surgery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70641","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:11:00Z","timestamp":1773997860000},"source":"Crossref","is-referenced-by-count":0,"title":["Esketamine hydrochloride in the management of moderate\u2010to\u2010severe depressive symptoms in patients undergoing multiple wound repair surgeries: A multi\u2010centre randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"16","author":[{"given":"Xiaomeng","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital  Beijing China"},{"name":"Chinese PLA Medical School  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1765-7418","authenticated-orcid":false,"given":"Tianqi","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology No. 984 Hospital of the PLA  Beijing China"},{"name":"Combat Trauma Center No. 984 Hospital of the PLA  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirui","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The First Medical Center of Chinese PLA General Hospital  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