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Although DNA damage\u2010regulated autophagy modulator 1 (DRAM1) plays a key role in autophagy, its involvement in glucocorticoid\u2010induced osteoporosis has not been fully explored. Here, we showed that alterations\u00a0in N\n                      <jats:sup>6<\/jats:sup>\n                      \u2010methyladenosine (m\n                      <jats:sup>6<\/jats:sup>\n                      A) levels contributed to the regulation of DRAM1 under dexamethasone treatment. In vitro, our research revealed that high doses of dexamethasone impaired the m\n                      <jats:sup>6<\/jats:sup>\n                      A\u2010dependent regulation of DRAM1 by YTH m\n                      <jats:sup>6<\/jats:sup>\n                      A RNA binding protein F1 (YTHDF1), leading to decreased DRAM1 levels and subsequent disruption of autophagy\u2010associated osteogenic differentiation in human bone marrow mesenchymal stem cells (hBMSCs) and MC3T3\u2010E1 cells. Additionally, the classic Wnt\/\u03b2\u2010catenin pathway, which plays a critical role in bone formation, was shown to be modulated by DRAM1 during osteogenic differentiation. In vivo experiments showed that DRAM1 protein expression in the femurs of Ythdf1 knockout (KO) mice was significantly lower than that\u00a0in the wild\u2010type (WT) group, and that resveratrol not only mitigated dexamethasone\u2010induced bone damage but was also associated with increased DRAM1 expression. These findings advance our understanding of how glucocorticoids hinder bone formation and suggest that targeting the m\n                      <jats:sup>6<\/jats:sup>\n                      A\u2010dependent YTHDF1\/DRAM1 regulatory axis may offer novel strategies for osteoporosis treatment.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70655","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T06:56:26Z","timestamp":1784789786000},"source":"Crossref","is-referenced-by-count":0,"title":["m\n                    <sup>6<\/sup>\n                    A\u2010modified DRAM1 recognized by YTHDF1 regulates autophagy during dexamethasone\u2010induced osteogenic inhibition"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3051-9183","authenticated-orcid":false,"given":"Ze\u2010Yu","family":"Lu","sequence":"first","affiliation":[{"name":"Spine Center Xinhua Hospital, Shanghai Jiao Tong 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