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But their role in carcinogenesis remains to be established. Thus, we established a clinical cohort and the faecal samples from CRC and healthy control were collected. Our metagenomic analysis found that the presence of\n                      <jats:italic>Parvimonas micra<\/jats:italic>\n                      exhibited the most significant relationship with the occurrence of CRC. Increased colonisation of\n                      <jats:italic>P. micra<\/jats:italic>\n                      in CRC was validated with analysis of 1379 faecal metagenomes from eight public cohorts. Untargeted metabolomics subsequently identified an accumulation of phenyllactic acid (PLA) in faecal samples from CRC patients. Higher concentration of PLA was detected in the supernatant from our isolated\n                      <jats:italic>P. micra<\/jats:italic>\n                      . Whole\u2010genome sequencing confirmed that a series of genes associated with PLA biosynthesis such as\n                      <jats:italic>pdhD<\/jats:italic>\n                      were observed in the\n                      <jats:italic>P. micra<\/jats:italic>\n                      genome. Importantly, both\n                      <jats:italic>P. micra<\/jats:italic>\n                      and PLA\u2010induced carcinogenesis in\n                      <jats:italic>Apc<\/jats:italic>\n                      <jats:sup>Min\/+<\/jats:sup>\n                      \u00a0and azoxymethane\/dextran sulphate sodium salt mice model. The roles of\n                      <jats:italic>P. micra<\/jats:italic>\n                      and PLA in CRC development were associated with DNA damage. Engineered\n                      <jats:italic>Escherichia coli BL21<\/jats:italic>\n                      that encoded the heterologous\n                      <jats:italic>pdhD<\/jats:italic>\n                      from\n                      <jats:italic>P. micra<\/jats:italic>\n                      could also induce DNA damage. Mechanically, PLA\u2010induced DNA damage and CRC carcinogenesis were significantly alleviated in\n                      <jats:italic>\n                        Ahr\n                        <jats:sup>\u2212\/\u2212<\/jats:sup>\n                      <\/jats:italic>\n                      mice. Aryl hydrocarbon receptor (AHR) inhibitor exhibited a therapeutic potential to reduce mice carcinogenesis. These findings established the role of\n                      <jats:italic>P. micra<\/jats:italic>\n                      and its metabolite, therefore providing diagnostic and therapeutic targets for treating CRC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70667","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:41:44Z","timestamp":1777866104000},"source":"Crossref","is-referenced-by-count":1,"title":["<i>Parvimonas micra<\/i>\n                    promotes carcinogenesis of colorectal cancer through phenyllactic acid\u2010induced DNA damage"],"prefix":"10.1002","volume":"16","author":[{"given":"Shuang","family":"Guo","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat\u2010Sen University  Guangzhou China"},{"name":"School of Public Health Sun Yat\u2010Sen University  Guangzhou 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