{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T07:24:17Z","timestamp":1787297057852,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYJC20132"],"award-info":[{"award-number":["ZYJC20132"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["2019HXFH034"],"award-info":[{"award-number":["2019HXFH034"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYJC21074"],"award-info":[{"award-number":["ZYJC21074"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune cells play a pivotal role in the pathogenesis of severe pneumonia. However, the global atlas of immune cells under this condition is not fully understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted single\u2010cell analyses of 275\u00a0411 cells isolated from matched lung tissue, bronchoalveolar lavage fluid, and peripheral blood from 12 patients with severe pneumonia and 5 donors, in order to identify the cross\u2010compartment sharing pattern of activated immune cells and the roles they play in severe pneumonia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our observations revealed that activated immune cells distributed across lung interstitia and airways (alveoli; Pattern 1a), including activated tissue\u2010resident memory\u2010like CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells (T8_rms), plasma cells and plasmablasts, and the pro\u2010inflammatory macrophages. The activated T8_rms were derived from circulating CX3CR1\n                      <jats:sup>+<\/jats:sup>\n                      CD8\n                      <jats:sup>+<\/jats:sup>\n                      T cells, which upregulated ITGAE and CXCR3 during lung infiltration. Similarly, plasma cells and plasmablasts expressing ITGAE and CXCR3 also indicated the potential lung interstitial\u2010to\u2010airway\/alveolar sharing pattern. The pro\u2010inflammatory macrophages interacted with T8_rms and plasma cells via the CXCL10\u2010CXCR3 axis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The lung interstitial\u2010to\u2010airway\/alveolar cross\u2010compartment sharing pattern of activated immune cells (Pattern 1a) provide a robust working hypothesis for clinical and translational research for severe pneumonia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70696","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:10:52Z","timestamp":1779347452000},"source":"Crossref","is-referenced-by-count":0,"title":["Activated immune cells present a lung interstitial\u2010to\u2010airway\/alveolar cross\u2010compartment sharing pattern in severe pneumonia"],"prefix":"10.1002","volume":"16","author":[{"given":"Yuean","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"State Key Laboratory of Respiratory Health and Multimorbidity West China Hospital, Sichuan University  Chengdu 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