{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T06:02:16Z","timestamp":1784959336724,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372172"],"award-info":[{"award-number":["82372172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis\u2010induced acute kidney injury (S\u2010AKI) is a major global public health concern, yet effective therapeutic strategies remain limited. Mitochondrial dysfunction in renal tissues is a key pathogenic mechanism underlying S\u2010AKI. GTS\u201021, a selective \u03b17 nicotinic acetylcholine receptor (\u03b17nAChR) agonist, exhibits anti\u2010inflammatory and renoprotective effects in S\u2010AKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We investigated the role of \u03b17nAChR in S\u2010AKI using both in vitro (lipopolysaccharide (LPS)\u2010induced renal tubular cell injury) and in vivo (caecal ligation and puncture (CLP)\u2010induced septic mice) models, with GTS\u201021 treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GTS\u201021 significantly attenuated mitochondrial dysfunction, suppressed apoptosis, and alleviated inflammation, thereby protecting renal tubular cells and renal tissues against LPS\u2010 and CLP\u2010induced injury. Mechanistically, GTS\u201021 activated \u03b17nAChR and\u00a0upregulated myocyte enhancer factor 2 (MEF2), peroxisome proliferator\u2010activated receptor gamma coactivator 1\u2010alpha (PGC\u20101\u03b1), and heme oxygenase\u20101 (HO\u20101), which collectively mediate its anti\u2010oxidative, anti\u2010apoptotic and anti\u2010inflammatory effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that GTS\u201021 may represent a potential therapeutic strategy for sepsis\u2010induced kidney injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70726","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:12:04Z","timestamp":1782198724000},"source":"Crossref","is-referenced-by-count":0,"title":["\u03b17nAChR agonist GTS\u201021 ameliorates sepsis\u2010induced acute kidney injury via MEF2\/PGC\u20101\u03b1\/HO\u20101 axis in mice"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4113-0779","authenticated-orcid":false,"given":"Yu\u2010Jia","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u2010Qi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nephrology The First Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang Province People's Republic of 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Heilongjiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Le","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Lin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine The Sixth Affiliated Hospital of Harbin Medical University  Harbin Heilongjiang Province People's Republic of 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