{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T07:00:27Z","timestamp":1784962827353,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873576"],"award-info":[{"award-number":["81873576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Metabolic dysfunction\u2010associated fatty liver disease (MAFLD) is a common chronic liver condition marked by abnormal lipid metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Small nucleolar RNA host gene 5 (SNHG5) is involved in the regulation of cell proliferation and apoptosis and was previously identified as a profibrotic factor in liver fibrosis. However, its role in MAFLD remains unclear. This study aimed to elucidate the contribution of SNHG5 to MAFLD progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>SNHG5 expression was markedly elevated during MAFLD progression, whereas SNHG5 inhibition suppressed lipid accumulation. Transcriptomic sequencing of primary hepatocytes overexpressing SNHG5 demonstrated significant downregulation of monocarboxylate transporter 1 (MCT1), a key lactate transporter. Integrated lactyl\u2010proteomic and proteomic analyses further revealed that SNHG5 overexpression promoted lactylation of the non\u2010histone protein AT\u2010rich interaction domain 1A (Arid1a) at K391, thereby driving excessive lipid accumulation. Acyltransferase assays indicated that both P300 and HBO1 participated in SNHG5\u2010mediated Arid1a lactylation. In vivo, hepatocyte\u2010specific SNHG5 knockout markedly attenuated hepatic lipid accumulation and MAFLD progression, whereas simultaneous hepatocyte\u2010specific deletion of SNHG5 and MCT1 restored lipid accumulation compared with SNHG5\u2010deficient mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SNHG5 promotes lipid accumulation and MAFLD progression through induction of MCT1\u2010mediated Arid1a K391 lactylation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70740","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:19:51Z","timestamp":1784956791000},"source":"Crossref","is-referenced-by-count":0,"title":["Role of LncSNHG5 in MAFLD: Mechanisms of Arid1a K391 lactylation and lipid accumulation"],"prefix":"10.1002","volume":"16","author":[{"given":"Xinmiao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1311-6769","authenticated-orcid":false,"given":"Binbo","family":"Fang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Intelligent Cancer Biomarker Discovery and Translation The First Affiliated Hospital of Wenzhou Medical University  Wenzhou 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