{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:23:23Z","timestamp":1787729003517,"version":"build-2784847793"},"reference-count":136,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies and is characterised by aggressive biological behaviour, marked therapeutic resistance and a dense desmoplastic tumour microenvironment. Integrin \u03b15\u03b21, the principal fibronectin receptor, has emerged as an important mediator of tumour\u2010stroma interactions through its roles in cell adhesion, mechanotransduction, migration, survival and extracellular matrix (ECM) remodelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body<\/jats:title>\n                    <jats:p>Increasing evidence indicates that integrin alpha 5 (ITGA5)\/integrin \u03b15\u03b21 is upregulated in PDAC cells and stromal compartments and is associated with invasion, fibrosis, therapeutic resistance and poor prognosis. Hypoxia, a defining feature of PDAC, may further enhance \u03b15\u03b21\u2010related signalling by promoting stromal activation and ECM remodelling. This review summarises the structural and signalling features of integrin \u03b15\u03b21, its role in hypoxia\u2010related interactions between tumour cells and the stroma, its contribution to therapeutic resistance in PDAC, and current therapeutic strategies targeting this integrin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Integrin \u03b15\u03b21 is a biologically relevant therapeutic target for modulating the fibrotic stroma and overcoming treatment resistance in PDAC, and it may also be implicated in tumorstroma crosstalk within the hypoxic microenvironment. Successful clinical translation of \u03b15\u03b21\u2010targeted strategies will likely require further mechanistic investigation, biomarker\u2010guided patient selection, and rational combination approaches to address pathway redundancy and the limited efficacy of monotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70759","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T13:47:23Z","timestamp":1786369643000},"source":"Crossref","is-referenced-by-count":1,"title":["Integrin \u03b15\u03b21 in pancreatic ductal adenocarcinoma: Tumour\u2012stroma crosstalk, hypoxia and therapeutic targeting"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-9113","authenticated-orcid":false,"given":"Chenzhe","family":"Ma","sequence":"first","affiliation":[{"name":"The Second Clinical Medical School Lanzhou University  Lanzhou China"},{"name":"Gansu Provincial Key Laboratory of Environmental Oncology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3851-2920","authenticated-orcid":false,"given":"Yingying","family":"Wang","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical School Lanzhou University  Lanzhou China"},{"name":"Gansu Provincial Key Laboratory of Environmental Oncology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-1412","authenticated-orcid":false,"given":"Yumin","family":"Li","sequence":"additional","affiliation":[{"name":"Gansu Provincial Key Laboratory of Environmental Oncology Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.35278"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003898"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217350"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010019\u20100238\u20101"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.07.041"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010020\u201001370\u20100"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.20892\/j.issn.2095\u20103941.2018.0304"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010021\u201007996\u20101"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201609037"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S273803"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000583\u20101"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.06.037"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.76232"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.62347\/GGVE9638"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(02)00971\u20106"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb\u20102007\u20108\u20105\u2010215"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010018\u20100038\u2010z"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201111077"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010018\u20100763\u2010x"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004696\u20101"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010023\u201001264\u20104"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108458"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2006.12.013"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/mjt.0000000000000053"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2016.07.011"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.01.011"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143239"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2019.04.002"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E21\u201012\u20100609"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.148.5.1075"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.123.319120"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0000000000001195"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.70788"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3727\/096504011X13079697132925"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.72367"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00673"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2748"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200404112"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158987"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201007\u20102878"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201013\u20100529"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.11.016"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111369"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01736\u201018"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201009453\u2010x"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092\u20108674(02)00935\u20102"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33507"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42977\u2010022\u201000120\u20109"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.157"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2013.06.008"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax2770"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1593\/tlo.11133"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073\u2010014\u20100105\u20103"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010022\u201001902\u2010w"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602132"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2024.5615"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000154455.86404.e9"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11060542"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602113"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.2015"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201054545\u20109"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20887"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2025.12986"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.03.018"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676\u2010200003000\u201000004"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081575"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002\u20109440(10)65005\u20105"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci14268"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.120.316857"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.81618"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhbp.6"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010023\u201002701\u2010x"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584\u2010024\u201001130\u20108"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15011"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143377"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568\u2010021\u201000340\u20106"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010026\u201008581\u20109"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1728730"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.246"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20748"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010023\u201001827\u20106"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4338"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/8611306"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.203342"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201098170\u20101"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2021.12817"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.79493"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.12.027"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010025\u201001310\u2010w"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209460"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2011.09.002"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1160\/th04\u201004\u20100261"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202504622R"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci122440"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010019\u20100608\u20101"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010018\u20100762\u20102"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.41008"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010025\u201001174\u20102"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018\u2010024\u201005537\u20100"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201001030\u2010w"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci159839"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201016\u20100338"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.01.060"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.86317"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.01.007"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010022\u201001259\u20106"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7151"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131215588"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402179"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25187"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297917090048"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.646985"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers5010027"},{"issue":"4","key":"e_1_2_13_115_1","first-page":"273","article-title":"Preclinical evaluation of an anti\u2010alpha5beta1 integrin antibody as a novel anti\u2010angiogenic agent","volume":"5","author":"Ramakrishnan V","year":"2006","journal-title":"J Exp Ther Oncol"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479\u20105876\u20105\u201061"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388\u2010020\u201001603\u20106"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.Ccr\u201008\u20100378"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2007.25.18_suppl.4549"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2010.12.362"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds281"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201010\u20101996"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010014\u20102576\u20108"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10\u20107097"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgg.2024.10.002"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.Mct\u201006\u20100100"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10958"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603171"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.10.022"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.Can\u201005\u20104105"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680701553052"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2008.08.005"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.Mcr\u201019\u20100442"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.Mcr\u201025\u20100104"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2015.26"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1315171"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010021\u201000284\u20104"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70759","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.70759","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:39:39Z","timestamp":1787726379000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.70759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":136,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/ctm2.70759"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.70759","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"e70759"}}