{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:23:25Z","timestamp":1787729005656,"version":"build-2784847793"},"reference-count":130,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["825B2083"],"award-info":[{"award-number":["825B2083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573268"],"award-info":[{"award-number":["82573268"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tumor\u2010associated neutrophils (TANs) serve as pivotal immune modulators in the tumor microenvironment and exert profound, context\u2010dependent effects on tumor immunity, yet their metabolic features and functional implications remain insufficiently explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body<\/jats:title>\n                    <jats:p>Throughout their lifecycle, neutrophils continuously sense and adapt to shifting microenvironments, maintaining survival and functional homeostasis through metabolic reprogramming. As key hubs of the tumor metabolic network, TANs exhibit pronounced metabolic plasticity and heterogeneity. Whether active or passive, TAN metabolic reprogramming critically contributes to immune evasion via multiple mechanisms, including regulation of immune mediator expression and intercellular metabolite crosstalk. Current research focuses on strategies that induce durable TAN metabolic reprogramming while overcoming inherent limitations, aiming to establish an efficient and safe TAN\u2010directed immunotherapeutic framework. In this review, we systematically summarize recent advances in TAN metabolic reprogramming, emphasizing its intrinsic link to immunological phenotypes and spatiotemporal heterogeneity. We also propose a TAN metabolic classification framework (4\u2010Tier TAN\u2010MetaC) and provide a comprehensive overview of translational opportunities, bottlenecks, and actionable future directions for TAN metabolism\u2010targeted immunotherapies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overall, TAN metabolic reprogramming represents a central driver of tumor immune evasion and a clinically actionable metabolic vulnerability for cancer immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Tumour\u2010associated neutrophil (TAN) metabolic reprogramming is tightly linked to their immunosuppressive functions.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Spatiotemporal metabolic heterogeneity shapes TAN\u2010mediated tumour immunity.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>A metabolism\u2010based TAN stratification model unifies cross\u2010study frameworks.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>TAN metabolism\u2010targeted immunotherapy holds promise for improving patient prognosis.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70780","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T07:15:52Z","timestamp":1786691752000},"source":"Crossref","is-referenced-by-count":0,"title":["Neutrophil\u2010based immunotherapy: A metabolic lens on mechanisms and therapeutic implications"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-9740","authenticated-orcid":false,"given":"Wenchao","family":"Xu","sequence":"first","affiliation":[{"name":"Department of General Surgery Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"},{"name":"Key Laboratory of Research in Pancreatic Tumor Chinese Academy of Medical Sciences  Beijing China"},{"name":"National Infrastructures for Translational Medicine Peking Union Medical College Hospital  Beijing China"},{"name":"State Key Laboratory of Complex, Severe, and Rare Diseases Peking Union Medical College 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