{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:12:05Z","timestamp":1790327525343,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018208","name":"Cure JM Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018208","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["K24AR076975"],"award-info":[{"award-number":["K24AR076975"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nailfold capillaroscopy is a non\u2010invasive method to visualize altered microcirculation in pediatric rheumatic disease, with potential to aid in diagnostic differentiation and disease monitoring. We used nailfold video capillaroscopy (NVC) and machine learning to identify patterns of capillaroscopic features in juvenile dermatomyositis (JDM) and associations of capillaroscopic features with clinical data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>NVC features were quantified using automated neural network\u2010based software in 76 individuals, including 18 controls, 33 JDM, 17 childhood\u2010onset systemic lupus erythematosus (cSLE), and 8 overlap myositis (OM) patients. Unsupervised cluster analysis by capillaroscopic features was performed, and clinical features were characterized by cluster. Differences in capillaroscopic features between disease groups were assessed using the Kruskal\u2013Wallis test. For JDM and OM patients, capillaroscopic and clinical feature associations were assessed using Spearman correlation. In 10 treatment\u2010na\u00efve myositis patients (JDM\u00a0+\u00a0OM), changes in capillaroscopic features between diagnosis and 3\u2010month follow\u2010up were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cluster analysis identified three patient clusters, characterized by the presence of either branched or enlarged capillaries, or absence of these abnormalities. The \u201cbranched\u201d cluster was most frequently assigned among JDM and OM and consisted of no controls. The majority of TIF1y+ JDM (4\/5) were in the \u201cbranched\u201d cluster. In JDM and OM, microhaemorrhage density correlated with disease duration (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u2212.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0033), physician global assessment score (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.6,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.0004), lactate dehydrogenase (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01), von Willebrand factor antigen (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.043), and neopterin (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.69,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). In 10 myositis patients, microhaemorrhage density decreased while capillary density increased from diagnosis to three months post\u2010treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A branched capillaroscopic pattern was observed more frequently in JDM and OM, particularly TIF1y+ JDM patients within our cohort. Microhaemorrhage density was the most changeable capillaroscopic feature and associated with markers of increased disease activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70789","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:04:01Z","timestamp":1788329041000},"source":"Crossref","is-referenced-by-count":0,"title":["Nailfold capillary phenotypes distinguish juvenile myositis subtypes and associate with disease activity"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6456-0005","authenticated-orcid":false,"given":"Nicholas","family":"McClellan","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4721-6668","authenticated-orcid":false,"given":"Sophia","family":"Matossian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Rynda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5951-4142","authenticated-orcid":false,"given":"Kirsten","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Janssen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4006-8945","authenticated-orcid":false,"given":"J. Michelle","family":"Kahlenberg","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1127-7879","authenticated-orcid":false,"given":"Jessica L.","family":"Turnier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Internal Medicine Division of Rheumatology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"2020 Pediatric Rheumatology Symposium","author":"Savani 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