{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:12:06Z","timestamp":1790327526340,"version":"4.1.0"},"reference-count":10,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical & Translational Med"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1002\/ctm2.70792","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:30:15Z","timestamp":1789547415000},"source":"Crossref","is-referenced-by-count":0,"title":["From immune checkpoint blockade to metabolic ecosystem intervention: A new perspective on ammonia\u2010mediated remodelling of tumour immunity"],"prefix":"10.1002","volume":"16","author":[{"given":"Yu","family":"Li","sequence":"first","affiliation":[{"name":"Collaborative Innovation Centre for Cancer Personalised Medicine and Hepatobiliary Centre The First Hospital Affiliated with Nanjing Medical University  Nanjing China"},{"name":"Department of General Surgery The Affiliated BenQ Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Centre for Cancer Personalised Medicine and Hepatobiliary Centre The First Hospital Affiliated with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3050-4383","authenticated-orcid":false,"given":"Jian","family":"Gu","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Centre for Cancer Personalised Medicine and Hepatobiliary Centre The First Hospital Affiliated with Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_1_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4060"},{"key":"e_1_2_1_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.06.081"},{"key":"e_1_2_1_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2017.06.003"},{"key":"e_1_2_1_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.08.016"},{"key":"e_1_2_1_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u201003045\u20102"},{"key":"e_1_2_1_11_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201017\u20101033"},{"key":"e_1_2_1_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.07.007"},{"key":"e_1_2_1_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2018.06.007"},{"key":"e_1_2_1_11_10_1","doi-asserted-by":"crossref","unstructured":"GuJ LiY ChenQ et\u00a0al.Tumor\u2010Produced ammonia is metabolized by regulatory T cells to further impede anti\u2010Tumor immunity.Cell.2026;189:418\u2010434 e424. doi:10.1016\/j.cell.2025.11.034","DOI":"10.1016\/j.cell.2025.11.034"},{"key":"e_1_2_1_11_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3593"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70792","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.70792","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70792","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:51:09Z","timestamp":1790326269000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.70792"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/ctm2.70792"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.70792","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"article-number":"e70792"}}