{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T06:33:46Z","timestamp":1792996426169,"version":"4.5.0"},"reference-count":170,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82672163"],"award-info":[{"award-number":["82672163"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001524"],"award-info":[{"award-number":["82001524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371681"],"award-info":[{"award-number":["82371681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2020CFB310"],"award-info":[{"award-number":["2020CFB310"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Protein lactylation is a recently identified post\u2010translational modification that reflects cellular metabolic status. It plays an important role in regulating gene expression and maintaining essential cellular functions. Dysregulation of lactylation has been implicated in the onset and progression of various human diseases. Programmed cell death (PCD) is a fundamental biological mechanism that determines cellular fate in response to internal and external stress. Although lactylation and PCD were initially regarded as distinct biological processes, recent studies have demonstrated that lactylation directly influences key transcriptional and signaling pathways involved in multiple PCD modalities, thereby reshaping cell\u2010death regulatory networks under pathological conditions. Nevertheless, the role of lactylation in regulating different forms of PCD across human diseases has not been fully clarified. In this review, we summarize emerging advances that reveal how histone and non\u2010histone lactylation modulate major PCD pathways and delineate the molecular mechanisms underlying lactylation\u2010mediated control of cell death programs. Moreover, we discuss the potential of lactylation\u2010related regulators to serve as promising biomarkers for disease prediction and as attractive targets for therapeutic intervention. Existing studies highlight that lactylation reshapes PCD regulatory circuits under pathological conditions. Lactylation\u2011associated molecules exhibit great potential as candidate biomarkers for disease prediction and actionable targets for therapeutic intervention. Overall, this review deepens our understanding of how protein lactylation influences programmed cell death and offers new insights into exploiting lactylation\u2010dependent mechanisms for targeted therapeutic development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key points<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Protein lactylation emerges as a key metabolic\u2013epigenetic regulator linking lactate metabolism to programmed cell death.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Histone and non\u2010histone lactylation orchestrate apoptosis, pyroptosis, ferroptosis and autophagy across diverse diseases.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Targeting lactylation\u2010related pathways provides promising opportunities for disease biomarkers and therapeutic intervention.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70795","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:40:38Z","timestamp":1790401238000},"source":"Crossref","is-referenced-by-count":0,"title":["Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases"],"prefix":"10.1002","volume":"16","author":[{"given":"Yue","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gynecology The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-8704","authenticated-orcid":false,"given":"Hengwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Zhongnan Hospital of Wuhan University  Wuhan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004842\u20109"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010024\u201001682\u20102"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom13030417"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114269"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.70049"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006449\u20108"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.794879"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010\u2010025\u201005279\u2010y"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010025\u201005278\u2010x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2023.11.003"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010022\u201000905\u2010x"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010022\u201000658\u2010w"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933\u2010025\u201002614\u2010x"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307216"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148\u2010025\u201001813\u20103"},{"key":"e_1_2_14_17_1","first-page":"534","article-title":"From energy metabolism to mood regulation: the rise of lactate as a therapeutic target","volume":"80","author":"Zhang S","year":"2025","journal-title":"J Adv Res"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010020\u20100243\u20104"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.12.001"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2022.42"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2022.07.004"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010019\u20101678\u20101"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1010516"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110911"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.10.015"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.11.005"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010024\u201001060\u2010w"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589\u2010024\u201001680\u20108"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2021.02.012"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25690"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201014\u20100319"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.008"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2020.02.006"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.23.10238"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010024\u201003303\u20104"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.10.005"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44370"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010024\u201001011\u20100"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107451"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2151"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000001983"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201646477"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.691134"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103627"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010023\u201000921\u20109"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2007.1674"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2025.100914"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.015"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109820"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.02.033"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010024\u201002008\u20109"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010021\u201000841\u20109"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2314128121"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007620\u20109"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.04.002"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.200187"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.11.005"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2024.101888"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2025.110602"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010025\u201000876\u20107"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi6696"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202200302"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.06.026"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966\u2010842X(00)01937\u20105"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124832"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010021\u201000507\u20105"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010025\u201003399\u20102"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010023\u201001195\u20106"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010024\u201001156\u20109"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.116952"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.777665"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872\u2010024\u201004251\u2010w"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00140"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.91284"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112869"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111791"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.10.011"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217696"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30687"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103194"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103553"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006246\u20103"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176007"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202402139R"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.09.021"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000002080"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2023.148373"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202414141"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409499"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103479"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408845"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010020\u20101138\u20104"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2697"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929\u2010020\u201000679\u20102"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806727115"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2249762"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.70069"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114119"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2025.2471633"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/wrr.13188"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2025.137310"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514\u2010024\u201000152\u20106"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010024\u201002943\u2010x"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202308099"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg4993"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202411943"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406026"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010024\u201006000\u20103"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.08.008"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14010051"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apcsb.2021.01.003"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2024.111032"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2023.148409"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.124.325049"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395\u2010024\u201001044\u20102"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2024.111468"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010024\u201001898\u20104"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154940"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106270"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935\u2010023\u201003082\u20107"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.3c00518"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201044779\u20101"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005952\u20104"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418\u2010024\u201001408\u20100"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.12.005"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202256052"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.07.011"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12033\u2010022\u201000643\u20105"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201055589\u2010w"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421\u2010025\u201000804\u20101"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046\u2010024\u201002972\u20106"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042025\u20108"},{"issue":"1","key":"e_1_2_14_136_1","first-page":"71","article-title":"Mechanism of lactic acidemia\u2010promoted pulmonary endothelial cells death in sepsis: role for CIRP\u2010ZBP1\u2010PANoptosis pathway","volume":"11","author":"Gong T","year":"2024","journal-title":"Mil Med Res"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495\u2010021\u201001682\u20100"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010025\u201005360\u2010z"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010025\u201002809\u2010x"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg9215"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2023.103007"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010025\u201002392\u20108"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010025\u201002366\u2010x"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002511\u20107"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xgen.2024.100506"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2024.08.004"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202406184"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14481"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3002394"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11010033"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201012\u20100131"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201023\u20103513"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1149989"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adc9465"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202305662"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201022\u20102263"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010023\u201002931\u2010y"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16332"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC\u201022\u20100344"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.70045"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2024.2430283"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc\u20102025\u2010012230"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010024\u201003658\u20103"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000001592"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.2c01551"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002468\u2010x"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1080\/17410541.2025.2473303"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840\u2010024\u201001799\u20107"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661\u2010023\u201011546\u20106"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420\u2010024\u201002139\u20104"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2021.09.009"}],"container-title":["Clinical and Translational Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70795","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ctm2.70795","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ctm2.70795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T05:39:53Z","timestamp":1792993193000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ctm2.70795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":170,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/ctm2.70795"],"URL":"https:\/\/doi.org\/10.1002\/ctm2.70795","archive":["Portico"],"relation":{},"ISSN":["2001-1326","2001-1326"],"issn-type":[{"value":"2001-1326","type":"print"},{"value":"2001-1326","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"article-number":"e70795"}}