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However, controversies remain in the field, such as the ambiguous role of sensory neurons in cancer progression and the potential pro\u2010tumorigenic risk of opioids. Notably, CRP regulates cancer progression through local pain\u2010associated mediators (e.g., CGRP, SP), the pain\u2010stress axis, central nuclei\u2010mediated peripheral immune modulation, sensory\u2010sympathetic\/vagal circuits and direct effects on tumour biology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Future research should further elucidate the mechanistic interplay between pain and cancer, as targeting CRP may offer novel therapeutic opportunities for anti\u2010cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms in neuroimmunology and cancer neuroscience.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Targeting pain in cancer may have promising therapeutic value in cancer progression.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70817","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:18:12Z","timestamp":1789193892000},"source":"Crossref","is-referenced-by-count":0,"title":["Cancer\u2010related pain: A bidirectional modulator of cancer 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Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7338-6413","authenticated-orcid":false,"given":"Biao","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9135-0940","authenticated-orcid":false,"given":"Peiwei","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"},{"name":"Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology  Shanghai People's Republic of 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