{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:12:04Z","timestamp":1790327524384,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ten percent of the global population presents impaired glucose tolerance. Although numerous interventions have been investigated to prevent type 2 diabetes (T2D), their comparative effectiveness remains uncertain. In this study, we assessed and ranked current pharmacological and non\u2010pharmacological interventions for preventing diabetes in individuals with prediabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study protocol was registered on PROSPERO (CRD42023473875). Randomised controlled trials (RCTs) reporting on adult patients with prediabetes undergoing any intervention addressing dysglycaemia were eligible. Our systematic search was conducted from database inception to 19 December 2025 in three databases (MEDLINE, Embase and Cochrane Library [CENTRAL]). Network meta\u2010analysis was performed using the random\u2010effect frequentist method. Our primary outcomes were the incidence of T2D, haemoglobin A1c (HbA1c), fasting plasma glucose (FPG) and 2\u2010h glucose after the glucose oral tolerance test (2hPG) expressed as relative risk (RR) and mean difference (MD), respectively, with the corresponding 95% confidence intervals (CIs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 378 RCTs comprising 113\u00a0122 patients. The highest risk reduction for T2D when compared with control was obtained with dual incretin\u2010based therapy (glucagon\u2010like peptide 1 [GLP\u20101] and gastric inhibitory polypeptide (GIP) receptor agonists [GLP\u20101\u00a0+\u00a0GIP RAs]) (RR\u00a0=\u00a0.1, CI [.05; \u00a0.21]), with GLP\u20101 receptor agonists (GLP\u20101 RAs) ranking second (RR\u00a0=\u00a0.26, CI [.19; \u00a0.4]) followed closely by metformin plus intensive lifestyle intervention (ILI) (RR\u00a0=\u00a0.27, CI [.12; \u00a0.64]). Only curcumin (MD\u00a0=\u00a0\u2212.49, CI [\u2212.70; \u2212.28]), dual GLP\u20101\u00a0+\u00a0GIP RA (MD\u00a0=\u00a0\u2212.46, CI [\u2212.63; \u2212.29]), single GLP\u20101 RA (MD\u00a0=\u00a0\u2212.41, CI [\u2212.50; \u2212.31]) and physical activity (MD\u00a0=\u00a0\u2212.35, CI [\u2212.48; \u2212.23]) achieved &gt;.3% HbA1c reductions after 1 year. Sulphonylureas and physical activity were most effective for the 1\u2010year FPG decrease, while the greatest 2hPG reduction was obtained with zinc supplementation and sulphonylureas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Incretin\u2010based therapies, particularly dual GLP\u20101\u00a0+\u00a0GIP RA and single GLP\u20101 RA, followed by metformin together with ILI, are the most effective interventions to prevent T2D in patients with prediabetes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70829","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:27:56Z","timestamp":1788931676000},"source":"Crossref","is-referenced-by-count":0,"title":["Evidence\u2010based ranking of diabetes prevention in prediabetes: A comprehensive network meta\u2010analysis of 378 randomised controlled 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