{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:12:01Z","timestamp":1790327521592,"version":"4.1.0"},"reference-count":112,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470551"],"award-info":[{"award-number":["82470551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2026NSFSC1692"],"award-info":[{"award-number":["2026NSFSC1692"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Piezo1 is a mechanosensitive cation channel that converts stretch, compression, and shear stress into calcium\u2010dependent signals. This narrative review evaluates how Piezo1 contributes to digestive physiology and disease and why divergent outcomes arise across experimental contexts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main body<\/jats:title>\n                    <jats:p>\n                      We searched PubMed\/MEDLINE, Embase, Web of Science, and Scopus from database inception to 15 July 2026, prioritising primary studies that used Piezo1\u2010specific genetic or pharmacological interventions. Piezo1\u2010specific evidence supports roles in epithelial junctional adaptation, mucus production, stem\u2010cell renewal, immune activation, injury, fibrosis, and gastrointestinal endocrine signalling. A contextual framework based on cell identity and state, mechanical stimulus, and tissue or disease phase helps explain these divergent effects. Transient physiological activation may support homeostasis and repair, whereas persistent or excessive activation can promote Ca\n                      <jats:sup>2+<\/jats:sup>\n                      overload, inflammasome signalling, mitochondrial dysfunction, and matrix remodelling. The strongest digestive\u2010system evidence for mechanometabolic coupling concerns macrophage glycolysis, enterocyte nutrient handling, and selected endocrine and lipid\u2010regulatory pathways. Evidence for Piezo1\u2010dependent lactate production remains model\u2010specific, and direct digestive evidence for lactylation is absent. One mechanistic mouse study supports hepatic endothelial regulation of bile\u2010acid synthesis, whereas intestinal Piezo1 control of bile\u2010acid homeostasis remains unestablished.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Therapeutic translation is limited by non\u2010selective tool compounds, broad tissue expression and the need for targeted delivery and phase\u2010appropriate modulation. Piezo1 is therefore best viewed as a context\u2010dependent mechanotransducer rather than a uniformly pathogenic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70832","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:03:51Z","timestamp":1789430631000},"source":"Crossref","is-referenced-by-count":0,"title":["Piezo1 in digestive homeostasis and disease: Barrier function, immune signalling, cellular injury and metabolism"],"prefix":"10.1002","volume":"16","author":[{"given":"Yuan","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology West China Hospital, Sichuan University  Sichuan Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology West China Hospital, Sichuan University  Sichuan Province 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