{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:21Z","timestamp":1791355941994,"version":"4.3.1"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170359"],"award-info":[{"award-number":["82170359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470354"],"award-info":[{"award-number":["82470354"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp;amp; Translational Med"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune checkpoint inhibitor\u2013associated myocarditis (ICIAM) is one of the immune\u2013related adverse events (irAEs) with low incidence but extremely high mortality. High\u2013dose glucocorticoid pulse therapy remains the recommended initial treatment for patients with ICIAM. However, an inadequate response to corticosteroid therapy is observed in some patients, who are subsequently classified as having steroid\u2010resistant immune checkpoint inhibitor\u2010associated myocarditis (srICIAM). Early combination of second\u2010line immunosuppression may represent an effective therapeutic strategy. However, Biomarkers capable of identifying such patients before treatment are currently lacking. We therefore sought to characterize circulating inflammatory proteins associated with corticosteroid responsiveness and to derive a preliminary serum\u2010based prediction model for steroid\u2010resistant ICIAM (srICIAM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum specimens obtained from patients with ICIAM at baseline and after methylprednisolone treatment were analyzed to quantify circulating immune\u2010related proteins using an antibody\u2010based proteomic assay. We developed a preliminary model for the early identification of patients at risk of srICIAM using proteins selected by three complementary machine\u2013learning algorithms and evaluated its discriminatory performance in an internal hold\u2010out cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Pretreatment serum samples from 47 patients with ICIAM were used to establish a protein\u2013based prediction model, with 33 patients assigned to model development and 14 to internal validation. Patients with a high srICIAM predictive score (\u2265.5625) based on CXCL9, TRANCE and MMP1 were more likely to show an inadequate early response to corticosteroid therapy and may warrant closer clinical monitoring and further evaluation. The analysis also revealed\u00a0that several serum immune proteins decreased in patients with ICIAM after methylprednisolone therapy. Serum CXCL9 levels were positively correlated with lactate dehydrogenase (LDH) and cardiac troponin T (cTnT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum immune proteins were dynamically altered in patients with ICIAM after methylprednisolone therapy. The preliminary score may enable earlier recognition of patients at risk of an inadequate corticosteroid response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70843","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:16:27Z","timestamp":1791353787000},"source":"Crossref","is-referenced-by-count":0,"title":["A serum proteomics\u2010based predictive model for steroid\u2010resistant immune checkpoint inhibitor associated myocarditis"],"prefix":"10.1002","volume":"16","author":[{"given":"Yerui","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Echocardiography Zhongshan Hospital Fudan University Shanghai Institute of Cardiovascular Diseases  Shanghai China"},{"name":"State Key Laboratory of Cardiovascular Diseases Zhongshan Hospital Fudan University  Shanghai China"},{"name":"Shanghai Institute of Medical Imaging Zhongshan Hospital Fudan University  Shanghai 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