{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:11:56Z","timestamp":1790327516457,"version":"4.1.0"},"reference-count":64,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC2022CRD011"],"award-info":[{"award-number":["SHDC2022CRD011"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical &amp; Translational Med"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Retinal neovascularization (RNV) causes irreversible vision loss. Despite the benefits of anti\u2010VEGF therapy, incomplete responses and persistent inflammation necessitate complementary treatments. Curcumin has anti\u2010inflammatory and anti\u2010angiogenic activity, but its poor solubility and bioavailability limit ocular application.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PLGA\u2010encapsulated curcumin nanoparticles (Cur\u2010NPs; approximately 125 nm) were produced using an ultrasound\u2010microreactor platform. Therapeutic efficacy was assessed in oxygen\u2010induced retinopathy (OIR) and Rho\/VEGF transgenic mouse models following intravitreal administration. Neovascularization, vascular leakage, retinal structure, apoptosis, retinal distribution, and intraocular retention were evaluated using histology, fluorescence imaging, and longitudinal in vivo imaging. Mechanisms were investigated using single\u2010cell transcriptomics, untargeted metabolomics, genetic loss\u2010of\u2010function, and pharmacological perturbation. Conbercept monotherapy and Cur\u2010NP combination treatment were also evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cur\u2010NPs reduced pathological neovascularization in both models and improved vascular integrity, decreased vascular leakage, preserved retinal architecture, and attenuated apoptosis in OIR mice. Compared with free curcumin, Cur\u2010NPs showed broader retinal fluorescence distribution and prolonged intraocular fluorescence retention. Cur\u2010NPs suppressed the NLRP3ASCCaspase\u20101 inflammasome and associated VEGF\/VEGFR2 signaling. Genetic and pharmacological experiments supported a functional contribution of NLRP3 signaling to the anti\u2010angiogenic effects of Cur\u2010NPs. Multi\u2010omics analyses revealed treatment\u2010associated changes in retinal immune\u2010cell states and metabolic pathways. ConberceptCur\u2010NP combination therapy reduced neovascularization more than either treatment alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cur\u2010NPs inhibit pathological RNV through modulation of NLRP3\u2010associated inflammatoryangiogenic signaling while improving retinal protection and intraocular retention. These findings support further evaluation of Cur\u2010NPs as a potential upstream anti\u2010inflammatory adjunct to VEGF\u2010directed therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ctm2.70846","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:58:02Z","timestamp":1790060282000},"source":"Crossref","is-referenced-by-count":0,"title":["Cascade\u2010targeted intervention of the NLRP3 inflammasome and downstream angiogenesis by curcumin nanoparticles for ocular neovascularization therapy"],"prefix":"10.1002","volume":"16","author":[{"given":"Siyu","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology Ruijin Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Cheng","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Cell and Therapeutic Antibody Ministry of Education 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